Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the <em>Plasmodium falciparum</em> dUTPase (Publications)
prepared show similar or slightly lower inhibition of PfdUTPase, and similar or weaker inhibition of parasite growth than the trityl compounds
Epidémiologie des helminthoses gastro-intestinales des petits ruminants dans la zone sylvo-pastorale au Sénégal (Publications)
(Moniezia expansa, Cysticercus tenuicollis) and 9 nematodes were identified. The most important parasite in sheep was Haemonchus contortus while Trichostrongylus colubriformis predominated in goats. The
MAP kinase kinase 1 (MKK1) is essential for transmission of <em>Trypanosoma brucei</em> by <em>Glossina morsitans</em> (Publications)
colonising the salivary glands. Transformation of null mutants with an ectopic copy of MKK1 enabled parasites to complete the life cycle in tsetse and infect mice. This is the first example of a gene that is
Heritability of gastrointestinal nematode faecal egg counts in West African village N'Dama cattle and its relation to age (Publications)
earlier suggestions that genetic control of faecal egg counts is most effective during periods of low parasite transmission. There was a significant (p
<em>myo</em>-inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in <em>Trypanosoma brucei</em> (Publications)
taken up via a specific proton-coupled electrogenic symport and that this transport is essential for parasite survival in culture. Down-regulation of the myo-inositol transporter using RNA interference inhibited
Discovery and preliminary structure-activity relationship analysis of 1,14-sperminediphenylacetamides as potent and selective antimalarial lead... (Publications)
Screening of synthesized and isolated marine natural products for in vitro activity against four parasitic protozoa has identified the ascidian metabolite 1,14-sperminedihomovanillamide (orthidine F, 1)
South-East Asia (Publications)
diseases and drug resistance. Reduced poverty in much of the region has reduced the prevalence of parasitic diseases, but the emergence and spread of artemisinin-resistant malaria and multidrug-resistant
<em>In vitro</em> activity of anti-malarial ozonides against an artemisinin-resistant isolate (Publications)
ozonides were highly effective against the dihydroartemisinin-resistant P. falciparum Cam3.IR539T parasites, showing a per cent survival ranging from
An evaluation of a lateral flow rapid diagnostic test for <em>Strongyloides stercoralis</em> infection (Publications)
diagnostic sensitivity was 97% (29/30). Group II comprised serum samples from patients with other parasitic infections (n=86) and Swiss blood donors (n=27); the RDT's diagnostic specificity for this group
Targeting the <em>Plasmodium falciparum</em> IspE enzyme (Publications)
enzyme IspE in Plasmodium falciparum is considered an attractive drug target, as it is essential for parasite survival and is absent in the human proteome. Yet it still has not been addressed by a small-molecule
