The flipside of eradicating a disease; human African trypanosomiasis in a woman in rural Democratic Republic of Congo: a case report (Publications)
Human African Trypanosomiasis (HAT) is a neglected disease caused by the protozoan parasites Trypanosoma brucei and transmitted by tsetse flies that progresses in two phases. Symptoms in the first phase
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors (Publications)
synthetase. These molecules are curative in mice at a single, low dose and show activity against all parasite life stages in multiple in vivo efficacy models. Our findings identify bicyclic azetidines with
Activity of diphenyl ether benzyl amines against human African trypanosomiasis (Publications)
Insect-borne parasite Trypanosoma brucei plagues humans and other animals, eliciting the disease Human African trypanosomiasis, also known as African sleeping sickness. This disease poses the biggest threat
Accuracy of the sedimentation and filtration methods for the diagnosis of schistosomiasis in cattle (Publications)
subjected to sedimentation and filtration for the diagnosis of schistosomiasis and other intestinal parasite infections. Schistosoma eggs or miracidia were discovered in 32 samples: 15 by filtration only,
Optimization of novel 1-methyl-1 h-pyrazole-5-carboxamides leads to high potency larval development inhibitors of the barber's pole worm (Publications)
screen of a diverse library of small molecules for inhibition of the development of larvae of the parasitic nematode Haemonchus contortus led to the identification of a 1-methyl-1 H-pyrazole-5-carboxamide
<em>In silico</em> guided reconstruction and analysis of ICAM-1-binding var genes from <em>Plasmodium falciparum</em> (Publications)
To test whether this is possible we have used a set of recently laboratory adapted ICAM-1-binding parasite isolates to generate sequence tags and, from these, to identify the full-length PfEMP1 being expressed
Current antifilarial drugs - mechanisms of action (Publications)
Filarial parasites of humans and animals represent a heterogeneous group of pathogenic nematodes, interacting throughout their life cycles with two hosts and, for most species, a bacterial endosymbiont
Swiss TPH Annual Report Is Out Now! (News)
https://www.swisstph.ch/en/news/news-detail/news/swiss-tph-annual-report-is-out-now
validation and application of new treatments such as for sleeping sickness, Chagas disease, malaria and parasitic worm infections. 2023 also marked the 80th anniversary of Swiss TPH. To commemorate this milestone
Treating Schistosomiasis in Pre-School Children (Page)
https://www.swisstph.ch/en/news/20170613-treating-schistosomiasis-in-pre-school-children
Sabina Beatrice-Matter Schistosomiasis, which is caused by flatworms, is one of the most prevalent parasitic diseases in Africa. One drug – praziquantel – is used in adults and school-aged children but there [...] dosage used to treat older children. Infection of schistosomiasis occurs when larval forms of the parasite – released by freshwater snails – penetrate the skin When left untreated, schistosomiasis can lead
Outbreak of <em>Cryptosporidium hominis</em> following river flooding in the city of Halle (Saale), Germany, August 2013 (Publications)
ted area. Health authorities should consider the potential health risks of long-term surviving parasites persisting on flooded grounds and in open waters even several weeks after the flooding and of bathing [...] bathing places close to sewage spill-overs. Preventive measures comprise water sampling (involving parasites), information of the public and prolonged closures of potentially contaminated sites.
