Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic... (Publications)
partial parasite clearance and disease recrudescence. Parenteral artesunate not followed up with oral ACT constitutes an artemisinin monotherapy and may favour the selection of resistant parasites. In connection
The R. Geigy Foundation Honours Efforts to Overcome 
Neglected Tropical Diseases (News)
https://www.swisstph.ch/en/news/news-detail/news/the-r-geigy-foundation-honours-efforts-to-overcome-neglected-tropical-diseases
low-income countries. Yet, worldwide, only a few research grants are available to fight these nasty parasites. Researchers, Giovanna Raso and Jean T. Coulibaly, seek to overcome this situation by better un [...] treating helminth infections. Thanks to his research, there is a test that can quickly detect the parasite causing bilharzia in the urine. Laborious stool examinations are no longer needed. Together with
Diagnosis and epidemiology of <em>Strongyloides stercoralis</em> in Cambodia (Publications)
examined, 191 (87.2%) had at least one intestinal parasitic infection. We could document 14 different parasitic species; eight helminthic and six protozoan parasites. In humans, most frequently diagnosed were [...] is a constant exposure to risk factors for STH-infection. Furthermore, specific details about the parasite, its biology and genetics, as well as transmission dynamics remain poorly understood. E.g., excreted [...] (80.8%), Spirometra spp. (21.3%) and Strongyloides spp. (14.9%)....
Diagnosis and epidemiology of <em>Strongyloides stercoralis</em> in Cambodia (Publications)
examined, 191 (87.2%) had at least one intestinal parasitic infection. We could document 14 different parasitic species; eight helminthic and six protozoan parasites. In humans, most frequently diagnosed were [...] is a constant exposure to risk factors for STH-infection. Furthermore, specific details about the parasite, its biology and genetics, as well as transmission dynamics remain poorly understood. E.g., excreted [...] (80.8%), Spirometra spp. (21.3%) and Strongyloides spp. (14.9%)....
Cardiac involvement in Chagas disease and African trypanosomiasis (Publications)
Trypanosomiases are diseases caused by various species of protozoan parasite in the genus Trypanosoma, each presenting with distinct clinical manifestations and prognoses. Infections can affect multiple
Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis (Publications)
proportional to the concentration of hemozoin, with a detection limit of 0.85 ng mL(-1). Malaria parasites in human blood can be detected down to 10 infected red blood cells muL(-1). The assay could potentially
Novel minor groove binders cure animal African trypanosomiasis in an<em> in vivo</em> mouse model (Publications)
been used for decades, have now lost efficacy in some places because of the emergence of resistant parasites. Consequently, the need for new chemotherapies is urgent. Here, we describe a structurally distinct
Design, synthesis, and biological evaluation of new 1-(Aryl-1<em>H</em>-pyrrolyl)(phenyl)methyl-1<em>H</em>-imidazole derivatives as antiprotozoal... (Publications)
the IC50 within the low nanomolar range against T. cruzi, with very high selectivity towards the parasite. Discussion of structure-activity relationships and in vitro biological data for the new compounds
Discovery of an orally active nitrothiophene-based antitrypanosomal agent (Publications)
Human African Trypanosomiasis (HAT), caused by Trypanosoma brucei gambiense and rhodesiense, is a parasitic disease endemic to sub-Saharan Africa. Untreated cases of HAT can be severely debilitating and fatal
Imaging of <em>Plasmodium</em> liver stages to drive next-generation antimalarial drug discovery (Publications)
Most malaria drug development focuses on parasite stages detected in red blood cells, even though to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic forms
