The low and declining risk of malaria in travellers to Latin America: is there still an indication for chemoprophylaxis? (Publications)
transmission and malaria imported by travellers to identify the utility of national and regional annual parasite index (API) in predicting malaria risk and its value in generating recommendations on malaria p
Trypanocidal, leishmanicidal and cytotoxic effects of anthecotulide-type linear sesquiterpene lactones from Anthemis auriculata (Publications)
leishmanicidal activity. 4-Hydroxyanthecotulide (2) appeared to be the most active compound against all parasites, particularly towards T. b. rhodesiense (IC(50) 0.56 microg/ml), whereas 4-acetoxyanthecotulide
Research Infrastructure at Swiss TPH | Excellence in Science (Page)
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development for tuberculosis, Chagas disease and Buruli ulcer. By studying real pathogens and culturing parasite life cycles, we are improving understanding of host-pathogen interactions and accelerating the discovery
Topics we work on | Research Areas at Swiss TPH (Page)
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implementation research - with a focus on poverty-related diseases. Malaria Neglected Tropical Diseases Parasitic Worm Infections Sleeping Sickness Tuberculosis Human Biomonitoring Gender and Health Non-Communicable
Antimalarial benzoheterocyclic 4-aminoquinolines: structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies (Publications)
antiplasmodial activity against K1 (multidrug resistant) and NF54 (sensitive) strains of the malaria parasite Plasmodium falciparum. Structure-activity relationship studies led to the identification of highly
A research agenda to underpin malaria eradication (Publications)
reducing the basic reproduction rate to less than 1, with the ultimate aim of eradication of the parasite from the human population. Sustained commitment from local communities, civil society, policy leaders
First report of <em>Echinococcus granulosus</em> (genotype G6) in a dog in Bamako, Mali (Publications)
negative by PCR. Sequence analysis of part of the NADH dehydrogenase subunit 1 gene identified the parasite as E. granulosus (genotype G6; Echinococcus canadensis). This is the first study to focus on the
The low and declining risk of malaria in travellers to Latin America: is there still an indication for chemoprophylaxis? (Publications)
transmission and malaria imported by travellers to identify the utility of national and regional annual parasite index (API) in predicting malaria risk and its value in generating recommendations on malaria p
3-Hydroxy-propanamidines, a new class of orally active antimalarials targeting <em>Plasmodium falciparum</em> (Publications)
al in vitro activity with nanomolar inhibition of chloroquine-sensitive and multidrug-resistant parasite strains ofPlasmodium falciparum (with IC50 values of 5 and 12 nM against 3D7 and Dd2 strains, r
Improved detection of intestinal helminth infections with a formalin ethyl-acetate-based concentration technique compared to a crude formalin... (Publications)
populations. The mainstay of diagnosis is the microscopic examination of faecal samples to detect parasites in the form of eggs, larvae and cysts. In an effort to improve the standard of care, the comparative