Targeting <em>Plasmodium</em> PI(4)K to eliminate malaria (Publications)
major human pathogens P. falciparum and P. vivax, and inhibit liver-stage hypnozoites in the simian parasite P. cynomolgi. We show that imidazopyrazines exert their effect through inhibitory interaction with
Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides (Publications)
The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant human suffering in the form of human African trypanosomiasis (HAT) and Chagas disease. Drugs currently available
A primaquine-chloroquine hybrid with dual activity against <em>Plasmodium</em> liver and blood stages (Publications)
components, with the intent to produce agents that exhibit bioactivity against different stages of the parasite's life cycle. In vitro, the hybrid molecule 3 displays activity against both asexual and sexual
2-Phenoxy-1,4-naphthoquinones: from a multitarget antitrypanosomal to a potential antitumor profile (Publications)
the development of further derivatives, able to finely modulate multiple pathways of cancer or parasite cell metabolism, might lead to more effective treatments against these devastating diseases
Identification of nuclear proteins that differentially interact with <em>Plasmodium falciparum</em> var gene promoters (Publications)
variation and cytoadherence of infected erythrocytes in malaria. Approximately 50 var genes per parasite genome code for this highly polymorphic surface protein. We showed recently that chromosome-central
Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes (Publications)
and TbB48). More than half of the compounds tested showed a submicromolar EC(50) against these parasites. The compounds did not display any cross-resistance to existing diamidine therapies, such as pentamidine
Eleganolone, a Diterpene from the French marine alga <em>Bifurcaria bifurcata</em> inhibits growth of the human pathogens <em>Trypanosoma brucei</em>... (Publications)
of French seaweed have been screened against Trypanosoma brucei rhodesiense trypomastigotes, the parasite responsible for sleeping sickness. These extracts have previously shown potent antiprotozoal activities
The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines (Publications)
seriously affects human health in Africa. Current therapies present limitations in their application, parasite resistance, or require further clinical investigation for wider use. Our work herein describes the
VectorDisk: a microfluidic platform integrating diagnostic markers for evidence-based mosquito control (Publications)
chambers and detection wavelengths (geometric and color multiplexing) to identify mosquito and malaria parasite species as well as insecticide resistance mechanisms. In the second study, purified nucleic acids
Similar prevalence of <em>Plasmodium falciparum</em> and Non-<em>P. falciparum</em> malaria infections among schoolchildren, Tanzania (Publications)
malariae, and 0.3% had P. vivax infections. Most (91%) schoolchildren with P. ovale infections had low parasite densities; 64% of P. ovale infections were single-species infections, and 35% of those were detected
