Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1 (Publications)
clefts. Change in location is accompanied by a change in solubility: from a soluble state within the parasite to a membrane-associated state after export to Maurer's clefts. No classical export motifs such
Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives (Publications)
A series of 44 4-aminopiperidine derivatives was screened in vitro against four protozoan parasites (Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum).
<em>Strongyloides stercoralis</em> is a cause of abdominal pain, diarrhea and urticaria in rural Cambodia (Publications)
almost entirely resolved. CONCLUSIONS: In rural communities of Cambodia, strongyloidiasis with high parasite load is endemic. It is associated with substantial symptoms and clinical signs, particularly abdominal
beta-Branched acyclic nucleoside analogues as inhibitors of <em>Plasmodium falciparum</em> dUTPase (Publications)
against uracil incorporation into DNA. Compounds were assayed against both PfdUTPase and intact parasites showing a correlation between enzyme inhibition and cellular assays. beta-Branched acyclic uridine
Ultrasonography of gallbladder abnormalities due to schistosomiasis (Publications)
After malaria, schistosomiasis remains the most important tropical parasitic disease in large parts of the world. Schistosomiasis has recently re-emerged in Southern Europe. Intestinal schistosomiasis
Antikinetoplastid antimitotic activity and metabolic stability of dinitroaniline sulfonamides and benzamides (Publications)
N(4)-di-n-butylsulfanilamide (2) show potent in vitro antimitotic activity against kinetoplastid parasites but display poor in vivo activity. Seventeen new dinitroaniline sulfonamide and eleven new benzamide
The discovery of novel antitrypanosomal 4-phenyl-6-(pyridin-3-yl)pyrimidines (Publications)
seriously affects human health in Africa. Current therapies present limitations in their application, parasite resistance, or require further clinical investigation for wider use. Our work herein describes the
VectorDisk: a microfluidic platform integrating diagnostic markers for evidence-based mosquito control (Publications)
chambers and detection wavelengths (geometric and color multiplexing) to identify mosquito and malaria parasite species as well as insecticide resistance mechanisms. In the second study, purified nucleic acids
Ultrasonography of gallbladder abnormalities due to schistosomiasis (Publications)
After malaria, schistosomiasis remains the most important tropical parasitic disease in large parts of the world. Schistosomiasis has recently re-emerged in Southern Europe. Intestinal schistosomiasis
<em>Strongyloides stercoralis</em> is a cause of abdominal pain, diarrhea and urticaria in rural Cambodia (Publications)
almost entirely resolved. CONCLUSIONS: In rural communities of Cambodia, strongyloidiasis with high parasite load is endemic. It is associated with substantial symptoms and clinical signs, particularly abdominal
