The troubled puberty of malaria parasites (Publications)
Sexual differentiation of malaria parasites is essential for transmission, yet the underlying mechanisms are poorly understood. Russell et al. elegantly combined a loss-of-function screen with single-cell
Parasite viability as a measure of <em>in vivo</em> drug activity in preclinical and early clinical antimalarial drug assessment (Publications)
in parasitemia (termed parasite clearance). We also observed that artesunate kills parasites faster at higher concentrations, which is not discernible from the traditional parasite clearance curve and that [...] trials. However, this metric does not distinguish between viable and nonviable parasites. Thus, enumeration of parasites may result in underestimation of drug activity for some compounds, potentially [...] estimating the decrease in parasite viability after treatment using two...
Inhibiting activities of the secondary metabolites of <em>Phlomis brunneogaleata</em> against parasitic protozoa and plasmodial enoyl-ACP reductase, a... (Publications)
Anti-plasmodial activity-guided fractionation of Phlomis brunneogaleata (Lamiaceae) led to the isolation of two new metabolites, the iridoid glycoside, brunneogaleatoside and a new pyrrolidinium deriv
Frequency of trypanosomosis and gastrointestinal parasites in draught donkeys in the Gambia in relation to animal husbandry (Publications)
Prevalence of trypanosomosis, gastrointestinal strongyles and level of strongyle egg outputs were studied in relation to husbandry practices in the draught donkey population in The Gambia. Feeding reg
Host cells participate in the in vitro effects of new-generation diamidine-analogues against tachyzoites of the intracellular apicomplexan parasites... (Publications)
dicationic diamidine-derivatives against the proliferative tachyzoite stages of the apicomplexan parasites Neospora caninum and Toxoplasma gondii were investigated. Four compounds (DB811, DB786, DB750 and [...] Electron microscopy of N. caninum-infected HFF cultures revealed distinct alterations and damage of parasite ultrastructure upon drug treatment, while host cells remained unaffected. To exert true parasiticidal [...] tachyzoites and subsequent culture in the absence of DB750, resulted in...