Eleganolone, a Diterpene from the French marine alga <em>Bifurcaria bifurcata</em> inhibits growth of the human pathogens <em>Trypanosoma brucei</em>... (Publications)
of French seaweed have been screened against Trypanosoma brucei rhodesiense trypomastigotes, the parasite responsible for sleeping sickness. These extracts have previously shown potent antiprotozoal activities
Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides (Publications)
The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant human suffering in the form of human African trypanosomiasis (HAT) and Chagas disease. Drugs currently available
Structure–activity relationship studies and <em>Plasmodium</em> life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl... (Publications)
potent in vitro activities against the asexual blood, liver and gametocyte stages of the Plasmodium parasite with no cross-resistance to chloroquine. Frontrunner lead compounds with good in vitro absorption
2-Phenoxy-1,4-naphthoquinones: from a multitarget antitrypanosomal to a potential antitumor profile (Publications)
the development of further derivatives, able to finely modulate multiple pathways of cancer or parasite cell metabolism, might lead to more effective treatments against these devastating diseases
Induced pluripotent stem cell-derived human macrophages as an infection model for <em>Leishmania donovani</em> (Publications)
The parasite Leishmania donovani is one of the species causing visceral leishmaniasis in humans, a deadly infection claiming up to 40,000 lives each year. The current drugs for leishmaniasis treatment
Symposium Professorship in Neglected Tropical Diseases (News)
https://www.swisstph.ch/en/news/news-detail/news/symposium-professorship-in-neglected-tropical-diseases
host immune response 11:50 – 12:30 PD Dr. Sabine Specht Vetsuisse, Universität Zürich Helminth Parasites - Friends or Foe?
Recent advances and potential future applications of MALDI-TOF mass spectrometry for identification of helminths (Publications)
present, diagnosis of helminthic diseases is mainly based on microscopic observation of different parasite stages, but microscopy is associated with limited diagnostic accuracy. Against this background,
Similar prevalence of <em>Plasmodium falciparum</em> and Non-<em>P. falciparum</em> malaria infections among schoolchildren, Tanzania (Publications)
malariae, and 0.3% had P. vivax infections. Most (91%) schoolchildren with P. ovale infections had low parasite densities; 64% of P. ovale infections were single-species infections, and 35% of those were detected
Malaria, climate variability, and interventions: modelling transmission dynamics (Publications)
coverage and use among the population. The model captures some of the main mechanisms of human, parasite, and vector dynamics, and opens the possibility to forecast malaria in endemic regions, taking into
Malaria elimination in Zanzibar: where next? (Publications)
management teams and inhabitants to authenticate desk review findings. A steady increase in the annual parasite incidence (API) was observed in Zanzibar, from 2.7 (2017) to 3.6 (2021) cases per 1,000 population
