Isolation of aerucyclamides C and D and structure revision of microcyclamide 7806A: heterocyclic ribosomal peptides from <em>Microcystis... (Publications)
aerucyclamide C were found against Trypanosoma brucei rhodesiense. The compounds were selective for the parasites over a cell line of L6 rat myoblasts and are thus considered for further study as antimalarial agents
Identification and characterization of trypanocides by functional expression of an adenosine transporter from <em>Trypanosoma</em> <em>brucei</em> in... (Publications)
carcinoma cells were 0.6 and 140 microM, respectively, indicating a good selectivity towards the parasites. Further studies are necessary to elucidate the effects of flavonoids on trypanosomal purine transport
Aminoalkyl derivatives of guanidine diaromatic minor groove binders with antiprotozoal activity (Publications)
minor groove whereas other set of compounds could exert this antimalarial activity by inhibiting the parasite dihydrofolate reductase, for example
Sudden emergence and spread of cutaneous larva migrans in Sudan: a case series calls for urgent actions (Publications)
Cutaneous larva migrans (CLM) is a self-limiting dermatosis parasitic disease that is caused by zoonotic hookworm mainly infects cats, dogs, and accidentally humans. The disease affects hosts through the
Medicinal chemistry optimization of a diaminopurine chemotype: toward a lead for <em>Trypanosoma brucei</em> inhibitors (Publications)
Human African trypanosomiasis (HAT), or sleeping sickness, is caused by the protozoan parasite Trypanosoma brucei and transmitted through the bite of infected tsetse flies. The disease is considered fatal
Spirombandakamine A3 and cyclombandakamines A8 and A9, polycyclic naphthylisoquinoline dimers, with antiprotozoal activity, from a Congolese... (Publications)
protozoal pathogen causing malaria, and moderate effects on Trypanosoma brucei rhodesiense, the parasite responsible for African sleeping sickness.
Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults (Publications)
of the proteome, providing first insights into naturally acquired and PfSPZ Vaccine-induced whole parasite antibody profiles in malaria pre-exposed Africans. Immunoreactivity was identified against 2,239
Enantiospecific antitrypanosomal<em> in vitro</em> activity of eflornithine (Publications)
treatment for the neglected tropical disease Gambian human African trypanosomiasis in late stage. This parasitic disease, transmitted by the tsetse fly, is lethal unless treated. Eflornithine is administered by
<em>Plasmodium falciparum</em>: malaria morbidity is associated with specific merozoite surface antigen 2 genotypes (Publications)
polymerase chain reaction for their respective MSA2 genotypes. We report that at the time of the study parasites carrying the FC27-like genotype were twice as likely to be found in symptomatic malaria cases than
Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in <em>Plasmodium falciparum</em> (Publications)
important role in chronic infection and severe malaria. Only a single var gene is transcribed per parasite, and epigenetic control mechanisms are fundamental in this strategy of mutually exclusive transcription
