Isolation of aerucyclamides C and D and structure revision of microcyclamide 7806A: heterocyclic ribosomal peptides from <em>Microcystis... (Publications)
aerucyclamide C were found against Trypanosoma brucei rhodesiense. The compounds were selective for the parasites over a cell line of L6 rat myoblasts and are thus considered for further study as antimalarial agents
Vaccine potentials of an intrinsically unstructured fragment derived from the blood stage-associated <em>Plasmodium falciparum</em> protein PFF0165c (Publications)
bands in Western blots, and were inhibitory in an in vitro antibody-dependent cellular inhibition parasite-growth assay. The immunological properties of P27A, together with its low polymorphism and association
Immunization of cattle with Ra86 impedes <em>Rhipicephalus appendiculatus</em> nymphal-to-adult molting (Publications)
however, does not extend to the three-host tick R. appendiculatus, the vector of the protozoan parasite Theileria parva. When transmitted to cattle, T. parva causes the often fatal disease East Coast
Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds (Publications)
evidence of the mode of action, indicating that the RCQ molecules inhibit hemozoin formation in the parasite's digestive vacuole in a manner similar to that of chloroquine
Aminoalkyl derivatives of guanidine diaromatic minor groove binders with antiprotozoal activity (Publications)
minor groove whereas other set of compounds could exert this antimalarial activity by inhibiting the parasite dihydrofolate reductase, for example
Identification and characterization of trypanocides by functional expression of an adenosine transporter from <em>Trypanosoma</em> <em>brucei</em> in... (Publications)
carcinoma cells were 0.6 and 140 microM, respectively, indicating a good selectivity towards the parasites. Further studies are necessary to elucidate the effects of flavonoids on trypanosomal purine transport
Antiprotozoal activities of traditional medicinal plants from the Garhwal region of North West Himalaya, India (Publications)
L RELEVANCE: In a search for new plant-derived biologically active compounds against protozoan parasites, an ethnopharmacological study was carried out to evaluate extracts from selected 17 traditional
Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African... (Publications)
was also evaluated in vitro against T. brucei rhodesiense as well as other related trypanosomatid parasites (i.e., Trypanosoma cruzi and Leishmania donovani).
Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues (Publications)
sickness calls for the prompt development of new safe and efficacious drugs. The pathogenic protozoan parasites lack the capability of synthesising purines de novo and they take up preformed purines from their
Antiprotozoal steroidal saponins from the marine sponge <em>Pandaros acanthifolium</em> (Publications)
methanolysates. The majority of the metabolites showed in vitro activity against three or four parasitic protozoa. Particularly active were the compounds 3 (pandaroside G) and its methyl ester (9), which
