An efficient system to generate monoclonal antibodies against membrane-associated proteins by immunisation with antigen-expressing mammalian cells (Publications)
we applied this approach successfully for three predicted GPI-anchored proteins of the malaria parasite Plasmodium falciparum. CONCLUSIONS: The described entirely cell-based technology is a fast and efficient
Repurposing of the open access malaria box for kinetoplastid diseases identifies novel active scaffolds against trypanosomatids (Publications)
to initiating new hit-to-lead activities, screening the Malaria Box against a plethora of other parasites would enable the community to better understand the similarities and differences between them. We
Identification of <em>T. brucei</em>-subgroup strains isolated from game (Publications)
b. rhodesiense. When testing T. b. brucei, the BIIT results depended on the number of incubated parasites and on the parasitaemia peak number the tested trypanosomes derived from. It was further shown that
A prospective study of <em>Plasmodium falciparum</em> multiplicity of infection and morbidity in Tanzanian children (Publications)
year of life, the incidence of clinical malaria was almost three times higher in children with parasites at baseline than in those without. In older children, baseline P. falciparum infections appeared
Activity of artemether and OZ78 against triclabendazole-resistant <em>Fasciola hepatica</em> (Publications)
zole is the drug of choice against Fasciola hepatica infections in humans and animals. However, parasite resistance against triclabendazole is spreading in the veterinary field, and there are no drugs
Genetically discrete populations of <em>Trypanosoma congolense</em> from livestock on the Kenyan coast (Publications)
on the Kenyan coast were characterized by isoenzyme electrophoresis and by the abilities of the parasite's DNA to hybridize to two repetitive sequence DNA probes. All the Kilifi stocks which were examined
Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles (Publications)
(IC(50) > 128 microM). Moreover, the best of these compounds were also tested against protozoan parasites, and some of these compounds were found to show activity, especially against Plasmodium falciparum
WHO Collaborating Centres (Page)
https://www.swisstph.ch/en/research/who-collaborating-centres
existing and developing new diagnostic tools, screening new compounds for efficacy and safety against parasitic worms, and assisting countries in establishing their control programmes. WHO Collaborating Centre
Development of a molecular snail xenomonitoring assay to detect <em>Schistosoma haematobium</em> and<em> Schistosoma bovis</em> infections in their... (Publications)
a DNA-based detection method for screening disease vectors, have been developed and trialed for parasites transmitted by hematophagous insects, such as filarial worms and trypanosomes, yet few have been
<em>Plasmodium falciparum</em>: extensive polymorphism in merozoite surface antigen 2 alleles in an area with endemic malaria in Papua New Guinea (Publications)
Forty-seven percent of the blood samples were positive for P. falciparum. The MSA2 alleles of this parasite population were characterized by PCR-RFLP genotyping. In 144 P. falciparum infections 38 different
