<em>Plasmodium falciparum Plasmodium</em> helical interspersed subtelomeric proteins contribute to cytoadherence and anchor <em>P. falciparum</em>... (Publications)
Adherence of Plasmodium falciparum infected erythrocytes to host endothelium is conferred through the parasite-derived virulence factor PfEMP1, the major contributor to malaria severity. PfEMP1 located at knob
Gambiense human African trypanosomiasis sequelae after treatment: a follow-up study 12 years after treatment (Publications)
microscopic examination or PCR. An oligosymptomatic presentation of HAT due to the persistence of parasites in compartments, where first stage HAT medications do not penetrate, could not be ruled out.
Evaluation of malaria diagnoses using a handheld light microscope in a community-based setting in rural Côte d'Ivoire (Publications)
ion with oil. Of the 223 samples, 162 (72.6%) were P. falciparum positive, and the overall mean parasite count was 1,392/muL of blood. Sensitivity and specificity of the handheld microscope was 80.2% (95%
TbIRK is a signature sequence free potassium channel from <em>Trypanosoma brucei</em> locating to acidocalcisomes (Publications)
channel named TbIRK. The protein is localized to acidocalcisomes in procyclic and in bloodstream form parasites. Functional properties of this channel were established after expression in Xenopus oocytes. Currents
Building community health resilience and alleviating poverty through multi-sectoral cooperation for elimination of schistosomiasis in Cambodia and Lao... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/building-community-health-resilience-and-alleviating-poverty-through-multi-sectoral-cooperation-for-elimination-of-schistosomiasis-in-cambodia-and-lao-peoples-democratic-republic
through the World Health Organization (WHO), and Swiss TPH together with the National Institute of Parasitic Diseases (NIPD) in Shanghai provide technical assistance to Lao PRD and Cambodia in the areas of
Resistance Evaluation and Surveillance Initiative for Schistosomiasis Treatment (RESIST) (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/resistance-evaluation-and-surveillance-initiative-for-schistosomiasis-treatment-resist
in Pemba (Zanzibar, Tanzania), where we hypothesise that MDA-driven selection of drug-resistant parasite strains is contributing to persistent transmission in hotspots. Recent revolutionary advances in
Clinical Immunology (Page)
https://www.swisstph.ch/en/about/mpi/clinical-immunology
We aim to identify surrogates of protection as well as host factors elicited by subunit and whole parasite vaccines against tuberculosis (TB) and malaria. Clinical trials are performed with our partners [...] Equatorial Guinea Malaria Vaccine Initiative SNF_FP_modelling - Multi-scale mathematical modelling of parasite, drug and vaccine interactions: optimising public health and disease elimination strategies PHS
Dual strategy to design new agents targeting <em>Schistosoma mansoni</em>: advancing phenotypic and <em>Sm</em>CB1 inhibitors for improved efficacy (Publications)
and optimized two lead structures from an in-house screening, with promising results against the parasitic flatworm Schistosoma mansoni and its target protease S. mansoni cathepsin B1 (SmCB1). Our correlation
<em>In vitro</em> and <em>in vivo </em>efficacy of diamidines against<em> Trypanosoma equiperdum</em> strains (Publications)
Trypanosoma equiperdum is a protozoan parasite responsible for causing Dourine, a debilitating neglected veterinary disease, found worldwide affecting equids. It is the only pathogenic trypanosome species
Alkaloid constituents of the amaryllidaceae plant amaryllis belladonna L (Publications)
and spectrometric methods, including GC-MS and 2D NMR. In vitro screening against four different parasitic protozoa (Trypanosoma cruzi, T. brucei rhodesiense, Leishmania donovani and Plasmodium falciparum)
