Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering (Publications)
had a weight of 9.5 mg and a drug load from 2.5% to 20%. Moxidectin, a drug used for treatment of parasitic infections, was used as a model compound. Drug content covered a range from 91% to 121% of the target
Deworming children for soil-transmitted helminths in low and middle-income countries: systematic review and individual participant data network... (Publications)
Intestinal parasites affect millions of children globally. We aimed to assess effects of deworming children on nutritional and cognitive outcomes across potential effect modifiers using individual participant
Multiplicity of asymptomatic <em>Plasmodium falciparum </em>infections and risk of clinical malaria: a systematic review and pooled analysis of... (Publications)
BACKGROUND: The malaria parasite Plasmodium falciparum holds an extensive genetic polymorphism. In this pooled analysis, we investigate how the multiplicity, i.e. the number of co-infecting clones, in
Immunization of malaria pre-exposed volunteers with PfSPZ Vaccine elicits long-lived IgM invasion-inhibitory and complement-fixing antibodies (Publications)
assessment of PfSPZ Vaccine-induced antibody responses could be more sensitive if they include parasite specific IgM in addition to IgG antibodies.
Mapping multiple components of malaria risk for improved targeting of elimination interventions (Publications)
implement vector control and surveillance activities based upon simple categorizations of annual parasite incidence. With technological advances, an enormous opportunity exists to better target specific
Isothermal microcalorimetry to study drugs against <em>Schistosoma mansoni</em> (Publications)
in vitro effect of praziquantel, oxamniquine, artesunate and mefloquine on metabolic activity and parasite motility of Schistosoma mansoni (newly transformed schistosomula (NTS) and 49 day-old adult worms)
Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines (Publications)
evaluated in vitro against T. b. rhodesiense (STIB900) trypomastigotes and Plasmodium falciparum NF54 parasites (erythrocytic stage). N-alkoxy and N-hydroxy derivatives showed weak micromolar range IC50 values
<em>In silico</em> prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against <em>Trypanosoma brucei... (Publications)
found up to present. Furanoheliangolide STLs were thus indentified as interesting leads against this parasite which deserve more detailed investigations
Antitrypanosomal isothiocyanate and thiocarbamate glycosides from <em>Moringa peregrina </em>[Letter] (Publications)
in vitro activity and its ability to irreversibly inhibit trypanothione reductase, an attractive parasite-specific target enzyme, 4-[(alpha-L-rhamnosyloxy) benzyl] isothiocyanate (4), can be considered
Predictive risk mapping of schistosomiasis in Brazil using Bayesian geostatistical models (Publications)
Schistosomiasis is one of the most common parasitic diseases in tropical and subtropical areas, including Brazil. A national control programme has been instigated in Brazil in the mid-1970s and proved
