A sero-epidemiological approach to explore transmission of <em>Mycobacterium ulcerans</em> (Publications)
were included in the study. While first serological responses to the mosquito transmitted malaria parasite Plasmodium falciparum and to soil transmitted Strongyloides helminths emerged around the age of
Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from... (Publications)
constituents in African taxa. Ancistectorine D (5) shows promising activities against the protozoan parasites Trypanosoma cruzi and Leishmania donovani, and it was likewise found to display strong cytotoxic
Host-directed therapies for infectious diseases: current status, recent progress, and future prospects (Publications)
progress in identifying host-directed therapies as adjunct treatment options for bacterial, viral, and parasitic infectious diseases.
Efficacy and side effects of praziquantel against <em>Schistosoma mansoni</em> in a community of western Côte d'Ivoire (Publications)
Praziquantel is efficacious against the adult stages of all human schistosome parasites, and has become the drug of choice for morbidity control of schistosomiasis. There is concern that resistance to
IgE antibodies are more species-specific than IgG antibodies in human onchocerciasis and lymphatic filariasis (Publications)
antigens showed that in all instances there was significantly less cross-reactivity with heterologous parasite antigens (i.e. higher species specificity) in the IgE antibody response to filarial infection than
Cyclic nucleotide-specific phosphodiesterases of <em>Plasmodium falciparum</em>: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral... (Publications)
ases (PDEs) have come into focus as interesting potential targets for PDE inhibitor-based anti-parasitic drugs. Genomes of the various agents of human malaria, most notably Plasmodium falciparum, all contain
Effect of single-dose oral artemether and tribendimidine on the tegument of adult <em>Clonorchis sinensis</em> in rats (Publications)
of trematodes plays a key role in nutrient absorption, exerts secretory functions, protects the parasite against the immune system of the host, and is a target for anti-trematocidal drugs. We performed
Optimized Malaria-antigens delivered by immunostimulating reconstituted influenza virosomes (Publications)
mortality in millions of individuals each year. The development of widespread resistance of the parasite to drugs as well as resistance of the transmitting mosquito-vector to insecticides in combination
Recent investigations of artemether, a novel agent for the prevention of <em>Schistosomiasis japonica, mansoni </em>and <em>haematobia</em> (Publications)
studies revealed that artemether exhibits the highest activity against juvenile stages of the parasites, while adult worms are significantly less susceptible. There was no indication of neurotoxicity
Antiplasmodial and antitrypanosomal activity of tanshinone-type diterpenoids from <em>Salvia miltiorrhiza</em> (Publications)
( 8), and cryptotanshinone ( 9). The IC (50)s of the compounds were determined against the two parasites and rat myoblast (L6) cells. They ranged from 4.1 microM to over 30 microM against P. FALCIPARUM
