Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against <em>Plasmodium falciparum</em> merozoite antigens (Publications)
s exist in natural immunisation. The correlations between ELISA and SPR were enhanced when only parasite positive samples were included, which may indicate that high affinity antibodies are difficult to
Ro 15-0216: a nitroimidazole compound active in vitro against human and animal pathogenetic African trypanosomes (Publications)
2-substituted nitroimidazole Ro 15-0216. For all trypanosome species, the concentration which inhibited parasite growth by 50% (IC50 value) was established: 0.0957 microgram ml-1 (T. b. brucei TC221), 0.1327 microgram
Medicinal plant preparations administered by Botswana traditional health practitioners for treatment of worm infections show anthelmintic activities (Publications)
transformed schistosomula (NTS)], Strongyloides ratti (threadworm) and Trichuris muris (nematode parasite of mice) in vitro. Extracts of two plants, Laphangium luteoalbum and Commiphora pyaracanthoides
Temporal and wash-out studies identify medicines for malaria venture pathogen box compounds with fast-acting activity against both <em>Trypanosoma... (Publications)
brucei sub-species, endemic to 36 countries within sub-Saharan Africa. Treatment regimens for these parasitic diseases are complicated and not effective against all disease stages; thus, there is a need to
Antiplasmodial and antitrypanosomal activity of tanshinone-type diterpenoids from <em>Salvia miltiorrhiza</em> (Publications)
( 8), and cryptotanshinone ( 9). The IC (50)s of the compounds were determined against the two parasites and rat myoblast (L6) cells. They ranged from 4.1 microM to over 30 microM against P. FALCIPARUM
Predictive risk mapping of schistosomiasis in Brazil using Bayesian geostatistical models (Publications)
Schistosomiasis is one of the most common parasitic diseases in tropical and subtropical areas, including Brazil. A national control programme has been instigated in Brazil in the mid-1970s and proved
<em>In silico</em> prediction and experimental evaluation of furanoheliangolide sesquiterpene lactones as potent agents against <em>Trypanosoma brucei... (Publications)
found up to present. Furanoheliangolide STLs were thus indentified as interesting leads against this parasite which deserve more detailed investigations
Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure (Publications)
on, community-based mobilization, and advocacy are vital to contain the emergence and spread of parasite resistance against new antimalarials
Cyclic nucleotide-specific phosphodiesterases of <em>Plasmodium falciparum</em>: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral... (Publications)
ases (PDEs) have come into focus as interesting potential targets for PDE inhibitor-based anti-parasitic drugs. Genomes of the various agents of human malaria, most notably Plasmodium falciparum, all contain
Antiprotozoal activity and DNA binding of N-substituted N-phenylbenzamide and 1,3-diphenylurea bisguanidines (Publications)
evaluated in vitro against T. b. rhodesiense (STIB900) trypomastigotes and Plasmodium falciparum NF54 parasites (erythrocytic stage). N-alkoxy and N-hydroxy derivatives showed weak micromolar range IC50 values
