Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
nucleus and will serve as an important platform for dissecting general and parasite-specific nuclear processes in malaria parasites. Moreover, as the first nuclear proteome characterized in any protist organism [...] post-genomic era of malaria research provided unprecedented insights into the biology of Plasmodium parasites. Due to the large evolutionary distance to model eukaryotes, however, we lack a profound understanding [...] ng of many processes in Plasmodium biology. One example is the...
Intestinal parasitic infections in HIV-infected patients, Lao People's Democratic Republic (Publications)
infection is an emerging problem in Laos. We conducted the first prospective study on intestinal parasites, including opportunistic protozoa, in newly diagnosed HIV infected patients, with or without diarrhea [...] at WHO stage 3 or 4, median CD4 cell count: 41/mm3). Diarrhea was present in 43.0% of patients. Parasite infection was found in 78.8% of patients, infection with at least two species in 49.6%. Prevalence
Exposure to multiple parasites is associated with the prevalence of active convulsive epilepsy in sub-Saharan Africa (Publications)
common in developing countries, and it is often associated with parasitic infections. We investigated the relationship between exposure to parasitic infections, particularly multiple infections and active convulsive
Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites (Publications)
The parasites that give rise to human African trypanosomiasis (HAT) are auxotrophs for various nutrients from the human host, including purines. They have specialist nucleoside transporters to import these [...] moiety to selected nitro heterocycles with the aim of selectively delivering these compounds to the parasites. Some compounds prepared have similar in vitro trypanocidal activities as melarsoprol, the principal
Intraspecific competition between co-infecting parasite strains enhances host survival in African trypanosomes (Publications)
for parasite-parasite and parasite-host interactions. To fully understand parasite and disease dynamics, the genetic diversity of infections must be taken into account. Through changes in parasite dynamics [...] It is becoming increasingly clear that under natural conditions parasitic infections commonly consist of co-infections with multiple conspecific strains. Multiple-strain infections lead to intraspecific [...] ic interactions and may have important ecological and evolutionary effects on...
Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites (Publications)
Human African trypanosomiasis (HAT), caused by the protozoan parasite Trypanosoma brucei spp., is a major health problem in sub-Saharan Africa. New drugs are urgently required for the disease. Selective
Nanomimics of host cell membranes block invasion and expose invasive malaria parasites (Publications)
falciparum parasites into red blood cells was selected as a biological model for the initial validation of this approach. Stable nanomimics-polymersomes presenting receptors required for parasite attachment [...] copolymer. The resulting nanomimics bound parasite-derived ligands involved in the initial attachment to host cells and they efficiently blocked reinvasion of malaria parasites after their egress from host cells [...] attachment to host cells-were designed to efficiently interrupt the...
