Safety and efficacy of the 10-day melarsoprol schedule for the treatment of second stage rhodesiense sleeping sickness (Publications)
rates were 8.4% (CI 3-13.8%) and 9.3% (CI 6-12.6%). All patients discharged alive were free of parasites at end of treatment. Twelve months after discharge, 96% of patients were clinically cured. The mean
Optimization of benzothiazole and thiazole hydrazones as inhibitors of schistosome bcl-2a (Publications)
Limited therapeutic options are available for the treatment of human schistosomiasis caused by the parasitic Schistosoma flatworm. The B cell lymphoma-2 (BCL-2)-regulated apoptotic cell death pathway in s
The relative contribution of co-infection to focal infection risk in children (Publications)
ubiquitous in people in the developing world but little is known regarding the potential for one parasite to act as a risk factor for another. Using generalized linear mixed modelling approaches applied
Risk factors for helminth infections in a rural and a peri-urban setting of the Dongting Lake area, People's Republic of China (Publications)
Schistosomiasis japonica and soil-transmitted helminthiasis are endemic parasitic diseases in the People's Republic of China (PR China). As very few studies have reported on the distribution and interaction
Update on the diagnosis and treatment of food-borne trematode infections (Publications)
investigations in rodents experimentally infected with Fasciola hepatica and Echinostoma caproni yielded parasite-specific candidate biomarkers, which might give rise to novel diagnostic targets. The FLOTAC technique
Safety, tolerability and immunogenicity of new formulations of the <em>Plasmodium falciparum </em>malaria peptide SPf66 combined with the... (Publications)
doses, respectively. Anti-SPf66 antibody from some subjects reacted against asexual blood stage parasites, as demonstrated by immunofluorescence and immunoblotting. Antibody responses generated by the QS-21
Remote sensing, geographical information system and spatial analysis for schistosomiasis epidemiology and ecology in Africa (Publications)
dynamics. Finally, more emphasis should be placed on risk mapping and prediction of multiple species parasitic infections in an effort to integrate disease risk mapping and to enhance the cost-effectiveness
In vitro trematocidal effects of crude alcoholic extracts of <em>Artemisia annua</em>, <em>A. absinthium</em>, <em>Asimina triloba</em>, and... (Publications)
indicates that their anthelmintic activity deserves further testing as natural alternative controls for parasites of both animals and humans. Our results also support recent evidence that synergistic effects of
Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives (Publications)
,2,4-trimethylquinolin-6-yl acetate (10a) displayed an IC(50) value of 0.014 muM against these parasites and a selectivity index of 1700. Intraperitoneal administration of 10a at 50 (mg/kg)/day for 4 days
Safety and immunogenicity of a three-component blood-stage malaria vaccine (MSP1, MSP2, RESA) against <em>Plasmodium falciparum</em> in Papua New... (Publications)
immunogenic in children aged 5-9 years. Vaccine immunogenicity was neither impaired by circulating parasites nor increased after pre-treatment with SP and pre-treatment is not advisable in future trials of
