Antigen-stimulated PBMC transcriptional protective signatures for malaria immunization (Publications)
cells from individuals immunized with RTS,S/AS01E or chemoattenuated sporozoites stimulated with parasite antigens in vitro. Specifically, we used samples of individuals from two age cohorts and three African
Two successful decades of Swiss collaborations to develop new anti-malarials (Publications)
development of these medicines. First, the country has a long history of understanding the biology of parasites and the pharmacology of drug responses through the leadership of the Swiss Tropical and Public Health
Mbandakamine-type naphthylisoquinoline dimers and related alkaloids from the central African liana <em>ancistrocladus ealaensis </em>with... (Publications)
(11-14). The new mbandakamines C (4) and D (5) showed pronounced activities against the malaria parasite Plasmodium falciparum, and they were likewise found to display strong cytotoxic activities against
Activities of psilostachyin A and cynaropicrin against <em>Trypanosoma cruzi</em> in vitro and in vivo (Publications)
membrane, and vesicular bodies and large vacuoles containing membranous structures, suggestive of parasite autophagy. Acute toxicity studies showed that one of two mice died at a cynaropicrin dose of 400
Occurrence of and risk factors for <em>Strongyloides stercoralis</em> infection in South-East Asia (Publications)
considered to be the best coprological diagnostic methods for field settings today. Both detect the parasite with high sensitivity. This sensitivity can be increased further by examining stool samples for
The regional network for Asian schistosomiasis and other helminth zoonoses (RNAS+): target diseases in face of climate change (Publications)
Climate change-according to conventional wisdom-will result in an expansion of tropical parasitic diseases in terms of latitude and altitude, with vector-borne diseases particularly prone to change. However
Evaluation of <em>in vitro</em> antiprotozoal activity of <em>Ajuga laxmannii </em>and its secondary metabolites (Publications)
traditionally used for the treatment of malaria, as well as fever, which is a common symptom of many parasitic diseases. Objective In the continuation of our studies on the identification of antiprotozoal secondary
Clonorchiasis (Publications)
so-called -omics sciences have not only advanced our knowledge of the biology and pathology of the parasite, but also led to the discovery of new diagnostic, drug, and vaccine targets. C sinensis infection
<em>Plasmodium </em>Helical Interspersed Subtelomeric (PHIST) proteins, at the Center of Host Cell Remodeling (Publications)
localization within the host cell, and there are few data on their interactions with other host or parasite proteins. However, over the past few years, PHIST proteins have been mentioned in the literature
Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode <em>Haemonchus contortus</em> (Publications)
Monepantel shows an excellent tolerability in mammals and is active against multidrug-resistant parasites, indicating that its molecular target is (i) absent or inaccessible in the host and (ii) different
