Novel 3-nitro-1H-1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents (Publications)
nM levels and SI 220 to 993). An NADH-dependent nitroreductase (TbNTR) plays a role in the anti-parasitic activity, since BSF T. b. brucei trypomastigotes with elevated TbNTR levels were hypersensitive
The malaria vaccine epidemiology and evaluation project of Papua New Guinea: rationale and baseline studies (Publications)
malaria vaccines, against different species of Plasmodium and various stages in the life cycle of the parasite in both human host and mosquito vector, is reviewed. The importance, in a malaria-endemic area,
<em>In vitro</em>, <em>ex vivo</em> and<em> in vivo</em> activity of diamidines against <em>Trypanosoma congolense</em> and <em>Trypanosoma vivax</em> (Publications)
Nagana. Dicationic compounds have demonstrated excellent efficacy against different kinetoplastid parasites. This study therefore evaluated the activity of 37 diamidines, using in vitro and ex vivo drug
Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control (Publications)
Schistosomiasis is a disease caused by parasitic trematode worms (schistosomes) that currently affects 200 million people living in tropical and subtropical environments. It is a chronic disease and the
The potential of artemether for the control of schistosomiasis (Publications)
Schistosomiasis continues to rank - following malaria - at the second position of the world's parasitic diseases in terms of the extent of endemic areas and the number of infected people. There is yet
Epidemiology and control of mekongi schistosomiasis (Publications)
implemented in Laos and in Cambodia. Operational research provided the necessary information on parasite epidemiology and the associated morbidity in order to develop adequate control measures. S. mekongi
New treatment option for second stage African sleeping sickness: In vitro and in vivo efficacy of aza analogs of DB289 (Publications)
African sleeping sickness is a fatal parasitic disease and all drugs currently in use for treatment have strong liabilities. It is essential to find new, effective and less toxic drugs ideally with oral
Evaluation of portable microscopic devices for the diagnosis of Schistosoma and soil-transmitted helminth infection (Publications)
SUMMARY The diagnosis of parasitic worm (helminth) infections requires specialized laboratory settings, but most affected individuals reside in locations without access to such facilities. We tested two
Estimating malaria transmission intensity from <em>Plasmodium falciparum</em> serological data using antibody density models (Publications)
to be particularly useful in areas of low transmission where traditional measures such as EIR and parasite prevalence are limited. The seroconversion rate (SCR) is usually estimated using catalytic models
Neglected diseases and ethnic minorities in the Western Pacific Region: exploring the links (Publications)
particularly vulnerable to neglected diseases, a diverse group of diseases that comprise bacteria, ecto-parasites, fungi, helminths and viruses. Despite the health policy relevance, only little is known of the
