Metabolic, pharmacokinetic, and activity profile of the liver stage antimalarial (RC-12) (Publications)
Phase I metabolites had no in vitro activity against P. vivax or P. cynomolgi liver-stage malaria parasites, we suggest that there may be additional unidentified active metabolites of 1 or that the exposure
Different classes of genomic inserts contribute to human antibody diversity (Publications)
from distant genes in antibody transcripts. Independent of the preexposure of donors to malaria parasites, non-VDJ inserts were detected in 80% of individuals at frequencies of 1 in 10(4) to 10(5) B cells
Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of <em>Scrophularia cryptophila</em> (Publications)
best and broadest spectrum activity was presented by compounds 3 and 7, as they inhibited all four parasitic protozoa. None of the isolates had significant activity against Mycobacterium tuberculosis (MICs
Mass screening and treatment on the basis of results of a <em>Plasmodium</em> <em>falciparum</em>-specific rapid diagnostic test did not reduce... (Publications)
PCR included non-falciparum species. Treatment of RDT positive individuals (4% of the PCR-detected parasite carriers) did not reduce subsequent malaria incidence compared with control areas. CONCLUSIONS:
Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant <em>Plasmodium falciparum</em>... (Publications)
these must therefore be carefully evaluated to ensure an uncompromised activity against real-life parasites. We report here the selection and phenotypic as well as genotypic characterization of a panel of
Diagnosis, treatment and risk factors of <em>Strongyloides stercoralis</em> in schoolchildren in Cambodia (Publications)
people are infected with Strongyloides stercoralis, a soil-transmitted helminth. Information on the parasite is scarce in most settings. In semi-rural Cambodia, we determined infection rates and risk factors;
Mefloquine - an aminoalcohol with promising antischistosomal properties in mice (Publications)
single drug, praziquantel. The large-scale use of praziquantel might select for drug-resistant parasites, hence there is a need to develop new antischistosomal compounds. Here, we report that the antimalarial
MalHaploFreq: a computer programme for estimating malaria haplotype frequencies from blood samples (Publications)
People infected with falciparum malaria often contain several genetically-distinct clones of the parasite; genotyping the patients' blood reveals whether or not the marker is present (i.e. its prevalence)
Quantifying nonvertical inheritance in the evolution of <em>Legionella pneumophila</em> (Publications)
nonvertical inheritance in Legionella pneumophila, a human pathogen and facultative intracellular parasite of amoebas. We have analyzed the exchange of L. pneumophila genetic material with other bacteria
The epidemiology of multiple <em>Plasmodium falciparum</em> infections. 9. Effect of insecticide-treated bed nets on haemoglobin values, prevalence... (Publications)
effects were more pronounced in younger children. However, no significant difference was observed in parasite density or multiplicity of infection among infected children. Comparison with PCR results indicated
