New diagnostic tools in schistosomiasis (Publications)
Schistosomiasis is a water-based parasitic disease that affects over 250 million people. Control efforts have long been in vain, which is one reason why schistosomiasis is considered a neglected tropical
Mass screening and treatment on the basis of results of a <em>Plasmodium</em> <em>falciparum</em>-specific rapid diagnostic test did not reduce... (Publications)
PCR included non-falciparum species. Treatment of RDT positive individuals (4% of the PCR-detected parasite carriers) did not reduce subsequent malaria incidence compared with control areas. CONCLUSIONS:
Antiprotozoal <em>Nor</em>-triterpene alkaloids from <em>Buxus sempervirens</em> L (Publications)
trypanosomiasis (HAT; sleeping sickness) are life-threatening tropical diseases caused by protozoan parasites. Due to limited therapeutic options, there is a compelling need for new antiprotozoal agents. In
The National Schistosomiasis Control Programme in Mali: objectives, organization, results (Publications)
Schistosoma mansoni exceeded 20% and/or the prevalence of persons with intensive infections for either parasite exceeded 5%. Intensive infection was defined as the excretion of more than 50 eggs per 10 ml of
(+/-)-<em>trans</em>-2-phenyl-2,3-dihydrobenzofurans as leishmanicidal agents: synthesis, <em>in vitro</em> evaluation and SAR analysis (Publications)
Leishmaniasis, a neglected tropical disease caused by parasites of the genus Leishmania, causes a serious burden of disease around the world, represents a threat to the life of millions of people, and
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors (Publications)
progression, leading to cell death. This research highlights a unique drug target for trypanosomatid parasitic protozoa and a new chemical tool for investigating the function of their divergent kinetochores
Mefloquine - an aminoalcohol with promising antischistosomal properties in mice (Publications)
single drug, praziquantel. The large-scale use of praziquantel might select for drug-resistant parasites, hence there is a need to develop new antischistosomal compounds. Here, we report that the antimalarial
Diagnosis, treatment and risk factors of <em>Strongyloides stercoralis</em> in schoolchildren in Cambodia (Publications)
people are infected with Strongyloides stercoralis, a soil-transmitted helminth. Information on the parasite is scarce in most settings. In semi-rural Cambodia, we determined infection rates and risk factors;
Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of <em>Scrophularia cryptophila</em> (Publications)
best and broadest spectrum activity was presented by compounds 3 and 7, as they inhibited all four parasitic protozoa. None of the isolates had significant activity against Mycobacterium tuberculosis (MICs
MalHaploFreq: a computer programme for estimating malaria haplotype frequencies from blood samples (Publications)
People infected with falciparum malaria often contain several genetically-distinct clones of the parasite; genotyping the patients' blood reveals whether or not the marker is present (i.e. its prevalence)
