A simulation model of African Anopheles ecology and population dynamics for the analysis of malaria transmission (Publications)
interventions. However, malaria remains uncontrolled and is increasing in many areas, as are vector and parasite resistance to insecticides and drugs. METHODS: This study presents a simulation model of African
Preclinical and clinical characteristics of the trichuricidal drug oxantel pamoate and clinical development plans: a review (Publications)
infections in humans. Oxantel pamoate acts locally in the human gastrointestinal tract and binds to the parasite's nicotinic acetylcholine receptor (nAChR), leading to a spastic paralysis of the worm and subsequent
Dynamics of gene introgression in the African malaria vector <em>Anopheles gambiae</em> (Publications)
However, the release of exotic transgenic mosquitoes will bring in novel alleles in addition to the parasite-inhibiting genes, which may have unknown effects on the local population. Therefore, it is necessary
The risk of malarial infections and disease in Papua New Guinean children (Publications)
acquired almost complete clinical immunity to P. vivax characterized by a very tight control of parasite density, whereas the acquisition of immunity to symptomatic P. falciparum malaria remained incomplete
Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant <em>Plasmodium falciparum</em>... (Publications)
these must therefore be carefully evaluated to ensure an uncompromised activity against real-life parasites. We report here the selection and phenotypic as well as genotypic characterization of a panel of
The roles of water, sanitation and hygiene in reducing schistosomiasis: a review (Publications)
caused by infection with blood flukes of the genus Schistosoma. Transmission of, and exposure to, the parasite result from faecal or urinary contamination of freshwater containing intermediate host snails, and
Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age (Publications)
Tanzania. The primary end point was fever with a falciparum parasitemia density of more than 2500 parasites per microliter, and the mean duration of follow-up was 7.9 months (range, 4.5 to 10.5). RESULTS:
The epidemiology of multiple <em>Plasmodium falciparum</em> infections. 8. Effect of iron supplementation and malaria prophylaxis in infants on... (Publications)
supplementation, a significant positive association was observed between the number of infections and parasite densities (Spearman's p = 0.25, P-0.047). This association was lost in the group receiving chem
The phenomenon of treatment failures in human African trypanosomiasis (Publications)
could be cured. The reason for relapses in the recent T. b. gambiense epidemics are not known. Other parasite-related factors might be involved, e.g. affinity to extravascular sites other than the CNS which
Different classes of genomic inserts contribute to human antibody diversity (Publications)
from distant genes in antibody transcripts. Independent of the preexposure of donors to malaria parasites, non-VDJ inserts were detected in 80% of individuals at frequencies of 1 in 10(4) to 10(5) B cells
