Metabolic, pharmacokinetic, and activity profile of the liver stage antimalarial (RC-12) (Publications)
Phase I metabolites had no in vitro activity against P. vivax or P. cynomolgi liver-stage malaria parasites, we suggest that there may be additional unidentified active metabolites of 1 or that the exposure
Effect of agricultural activities on prevalence rates, and clinical and presumptive malaria episodes in central Côte d'Ivoire (Publications)
of severe malaria episodes (i.e. axillary temperature> 37.5 degrees C plus parasitaemia> 5000 parasites/mul blood). Our study underscores the complex relationship between malaria transmission, prevalence
Acridine Orange for malaria diagnosis: its diagnostic performance, its promotion and implementation in Tanzania, and the implications for malaria... (Publications)
sensitivities of 81.3%-100% and specificities of 86.4%-100%. However, sensitivities decrease with lower parasite densities, and species differentiation may occasionally be difficult. The most notable advantage
Neglected diseases and ethnic minorities in the Western Pacific Region: exploring the links (Publications)
particularly vulnerable to neglected diseases, a diverse group of diseases that comprise bacteria, ecto-parasites, fungi, helminths and viruses. Despite the health policy relevance, only little is known of the
Activities of psilostachyin A and cynaropicrin against <em>Trypanosoma cruzi</em> in vitro and in vivo (Publications)
membrane, and vesicular bodies and large vacuoles containing membranous structures, suggestive of parasite autophagy. Acute toxicity studies showed that one of two mice died at a cynaropicrin dose of 400
The regional network for Asian schistosomiasis and other helminth zoonoses (RNAS+): target diseases in face of climate change (Publications)
Climate change-according to conventional wisdom-will result in an expansion of tropical parasitic diseases in terms of latitude and altitude, with vector-borne diseases particularly prone to change. However
Malaria vaccines: a toy for travelers or a tool for eradication? (Publications)
malaria in Mozambique, and an asexual blood-stage vaccine combining MSP1/MSP2/RESA that reduced parasite density in Papua New Guinea, allows one to believe that a malaria vaccine will be available for
New treatment option for second stage African sleeping sickness: In vitro and in vivo efficacy of aza analogs of DB289 (Publications)
African sleeping sickness is a fatal parasitic disease and all drugs currently in use for treatment have strong liabilities. It is essential to find new, effective and less toxic drugs ideally with oral
The potential of artemether for the control of schistosomiasis (Publications)
Schistosomiasis continues to rank - following malaria - at the second position of the world's parasitic diseases in terms of the extent of endemic areas and the number of infected people. There is yet
Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control (Publications)
Schistosomiasis is a disease caused by parasitic trematode worms (schistosomes) that currently affects 200 million people living in tropical and subtropical environments. It is a chronic disease and the
