Investigation of indolglyoxamide and indolacetamide analogues of polyamines as antimalarial and antitrypanosomal agents (Publications)
respectively). To expand the structure-activity relationship of this compound class towards both parasites, we have prepared and biologically tested a library of analogues that includes indoleglyoxyl and
Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity (Publications)
African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei
Repositioning and characterization of 1-(pyridin-4-yl)pyrrolidin-2-one derivatives as <em>Plasmodium </em>cytoplasmic prolyl-trna synthetase... (Publications)
relative high propensity to develop resistance in vitro (minimum inoculum resistance of 8 x 10(5) parasites at a selection pressure of 3 x IC50) constitute unfavorable features for treatment of malaria. However
A stable, oligosymptomatic malaria focus in Thailand (Publications)
of a non-migratory farming village in south-eastern Thailand was visually examined for malaria parasites monthly for 2 years. Nearly 97% of the population had at least one (median = 5) patent Plasmodium
Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases (Publications)
ivermectin) is being investigated but showed variable treatment efficacies without evidence of intrinsic parasite resistance. Here, we analyzed the microbiome of Trichuris trichiura and hookworm-infected patients
Epidemiology and risk factors of <em>Strongyloides stercoralis </em>infection in Papua, Indonesia: a molecular diagnostic study (Publications)
Strongyloides stercoralis is a parasitic worm that is of considerable clinical relevance. Indeed, it may persist asymptomatically for many years, but can lead to potentially fatal dissemination when the
An individual-based model of <em>Plasmodium falciparum</em> malaria transmission on the coast of Kenya (Publications)
immigration (> 0.3%) by infected people into the community could prevent local extinction of the parasite. In intermediate and high transmission areas, reduction in prevalence is short-lived and the probability
Nutrition as an etiological factor causing diseases in endangered huemul deer (Publications)
population also has cases with cranial osteopathologies, high disease susceptibility (parapoxvirus, parasitism, foot lesions), crippled antlers, and low density, indicative of marginal habitat and primary
Nonrandom selection and multiple blood feeding of human hosts by <em>Anopheles </em>vectors: implications for malaria transmission in Papua New Guinea (Publications)
higher in this age group, suggesting males in this age range could be super-spreaders of malaria parasites. The proportion of mosquitoes that fed on multiple humans ranged from 6% to 13% among villages.
Laboratory-based efficacy evaluation of <em>Bacillus thuringiensis</em> var. <em>israelensis </em>and temephos larvicides against larvae of... (Publications)
invasive Anopheles stephensi, capable of transmitting Plasmodium vivax and Plasmodium falciparum parasites was first reported in Ethiopia in 2016. The ecology of An. stephensi is different from that of Anopheles
