Microhabitat preferences of <em>Biomphalaria pfeifferi</em> and <em>Lymnaea natalensis</em> in a natural and a man-made habitat in southeastern... (Publications)
Schistosoma mansoni is an important human parasitic disease which is widespread throughout Africa. As Biomphalaria pfeifferi snails act as intermediate host, knowledge of their population ecology is an
Compounds structurally related to ellagic acid show improved antiplasmodial activity (Publications)
downregulation of most antioxidant genes studied and impaired mainly the trophozoite stage of the parasites. In addition, EA, CEA, and FEA were found to strongly inhibit in vitro heme aggregation. In vitro
Investigation of indolglyoxamide and indolacetamide analogues of polyamines as antimalarial and antitrypanosomal agents (Publications)
respectively). To expand the structure-activity relationship of this compound class towards both parasites, we have prepared and biologically tested a library of analogues that includes indoleglyoxyl and
malERA: an updated research agenda for characterising the reservoir and measuring transmission in malaria elimination and eradication (Publications)
is better understood, as are the biological parameters governing transmission of sexual stage parasites. Limitations of existing transmission measures have been documented, and proof-of-concept has been
Mapping hotspots of malaria transmission from pre-existing hydrology, geology and geomorphology data in the pre-elimination context of Zanzibar,... (Publications)
malaria elimination programmes, especially for tackling outdoor biting species and for eliminating parasite and vector populations when they are most vulnerable during the dry season. Effective larval source
Synthesis and biological evaluation of organoruthenium complexes with azole antifungal agents. First crystal structure of a tioconazole metal complex (Publications)
showed statistically significant effects. Mcz and its complexes were also tested against the human parasite Schistosoma mansoni and revealed schistocidal activity at 10-100 mu g/mL in vitro
Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana <em>Ancistrocladus abbreviatus</em> with inhibitory... (Publications)
compounds. Some of the alkaloids of A. abbreviatus exhibited promising activities against the malaria parasite Plasmodium falciparum and PANC-1 human pancreatic cancer cells.
Assessment of tegumental damage to <em>Schistosoma mansoni </em>and <em>S. haematobium </em>after <em>in vitro</em> exposure to ferrocenyl,... (Publications)
BACKGROUND: Schistosomiasis is one of the most harmful parasitic diseases worldwide, praziquantel being the only drug in widespread use to treat it. We recently demonstrated that ferrocenyl, ruthenocenyl
Ixodid tick species and two tick-borne pathogens in three areas in the Sudan (Publications)
Ticks are important parasites from economic and public health points of view because of their ability to reduce farm animals' productivity and transmit zoonotic diseases. We conducted this cross-sectional
Dioncophyllines C2, D2, and F and related naphthylisoquinoline alkaloids from the Congolese liana <em>Ancistrocladus ileboensis</em> with potent... (Publications)
Moreover, the dioncophyllines 1, 3, and 7 showed high-and specific-activities against the malaria parasite Plasmodium falciparum.
