Assessing anti-<em>T. cruzi</em> candidates<em> in vitro</em> for sterile cidality (Publications)
infected after 96 h of drug incubation in the presence of CYP51 inhibitors-albeit at a very low parasite load. These residual T. cruzi amastigotes were shown to be viable and infective, as demonstrated
A worldwide map of <em>Plasmodium falciparum</em> K13-propeller polymorphisms (Publications)
we observed a broad array of rare nonsynonymous mutations that were not associated with delayed parasite clearance. The gene-edited Dd2 transgenic line with the A578S mutation, which expresses the most
Double trouble: visceral leishmaniasis in twins after traveling to Tuscany - a case report (Publications)
Diagnosis of visceral leishmaniasis was confirmed by presence of intracytoplasmic localised leishmania parasites on bone marrow aspirate and/or positive leishmania serology. Both girls responded well to treatment
Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity (Publications)
African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei
Associations between selective attention and soil-transmitted helminth infections, socioeconomic status, and physical fitness in disadvantaged... (Publications)
children's capacity to pay attention. The present study examines how socioeconomic status (SES), parasitic worm infections, stunting, food insecurity, and physical fitness are associated with selective attention
Detection of <em>Plasmodium falciparum</em> infected <em>Anopheles gambiae</em> using near‑infrared spectroscopy (Publications)
could revolutionize surveillance and elimination strategies for the most important human malaria parasite in its primary African vector species. Further research is needed to evaluate how the method performs
Combined stool-based multiplex PCR and microscopy for enhanced pathogen detection in patients with persistent diarrhoea and asymptomatic controls from... (Publications)
detection tests for the diagnosis of diarrhoeagenic pathogens. Overall, 20 different bacteria, parasites and viruses were detected by the suite of diagnostic methods employed. At least one pathogen was
Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity (Publications)
pentamidine-uptake, and melarsoprol treatment-failure has been found to be due to AQP2-defects in these parasites. To further probe the roles of these transporters, we assembled a T. b. brucei strain lacking all
Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis (Publications)
Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high
SNSF Professorship Awarded to Melissa Penny (News)
https://www.swisstph.ch/en/news/news-detail/news/snsf-professorship-awarded-to-melissa-penny
professorship entails a four-year research project entitled “Multi-scale mathematical modelling of parasite, drug and vaccine interactions: optimising public health and disease elimination strategies”. The
