Validation of a human-serum-based <em>in vitro </em>growth method for drug screening on juvenile development stages of <em>Schistosoma mansoni</em> (Publications)
treatment and control. Drug discovery is often based on phenotypic drug screening, involving different parasite stages retrieved from infected mice. Aiming to reduce animal use, we validated an in vitro growth
Performance of a rapid immuno-chromatographic test (<em>Schistosoma</em> ICT IgG-IgM) for detecting <em>Schistosoma</em>-specific antibodies in sera... (Publications)
BACKGROUND: Schistosomiasis, an acute and chronic parasitic disease caused by human pathogenic Schistosoma species, is a neglected tropical disease affecting more than 220 million people worldwide. For
Population genetic structure of <em>Schistosoma haematobium</em> and <em>Schistosoma haematobium</em> x <em>Schistosoma bovis</em> hybrids among... (Publications)
West and the three sites in the East. Analysis at the infrapopulation level revealed clustering of parasite genotypes within individual children, particularly in Duekoue (West) and Sikensi (East). Of the
A new nonpolar N-hydroxy imidazoline lead compound with improved activity in a murine model of late stage <em>Trypanosoma brucei brucei</em> infection... (Publications)
late-stage sleeping sickness requires drugs that can cross the blood-brain barrier (BBB) to reach the parasites located in the brain. We report here the synthesis and evaluation of four new N-hydroxy and twelve
Risk profiling of schistosomiasis using remote sensing: approaches, challenges and outlook (Publications)
Schistosoma infection to remotely sensed data did not reflect that there is a spatial gap between the parasite and intermediate host snail habitats where disease transmission occurs, and the location (community
Experience of safety monitoring in the context of a prospective observational study of artemether-lumefantrine in rural Tanzania: lessons learned for... (Publications)
one under metakelfin, two after antibiotics; the remaining seven were due to anti-pyretic or anti-parasite medications. Twenty patients experienced SAEs; in 16 cases, a relation to AL was suspected. Six
Identification of cryptic <em>Anopheles</em> mosquito species by molecular protein profiling (Publications)
cally identical sibling species that play different roles in the transmission of pathogens and parasites. Currently PCR diagnostics are used to distinguish between sibling species. PCR based methods are
Modelling the epidemiological impact of intermittent preventive treatment against malaria in infants (Publications)
potential benefits of avoiding fevers on immunity and the effect of sub-therapeutic levels of SP on parasite dynamics. The baseline model reproduced the pattern of results reasonably well. None of the models
Rifampicin/Cotrimoxazole/Isoniazid versus mefloquine or quinine + sulfadoxine- pyrimethamine for malaria: a randomized trial1 (Publications)
population (72 Cotrifazid, 71 mefloquine, and 75 quinine + SP), clinical failure rate (symptoms and parasite load) on day 14 was equivalent for the three groups (0% for Cotrifazid and mefloquine; 1% for quinine
Age-independent osteopathology in skeletons of a South American cervid: the Patagonian huemul (<em>hippocamelus bisulcus</em>) (Publications)
fulminating infections; congenital anomalies; metabolic, endocrine, genetic, or neurologic disorders; parasitism or marasmus; and fluorosis as primary etiologic factors. We hypothesize that generalized secondary
