Mathematical modelling to examine disease, control measures, vaccine interactions and resistance to guide public health and disease elimination... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/mathematical-modelling-to-examine-disease-control-measures-vaccine-interactions-and-resistance-to-guide-public-health-and-disease-elimination-strategies
policies and vaccine roll-out plans over the coming years. We will build and calibrate detailed parasite models, mosquito-to-human transmission models and adapt individual-level models for malaria. We
Nationwide school malaria parasitaemia survey in public primary schools, the United Republic of Tanzania (Publications)
August to September 2014; (2) May 2015; and, (3) October 2015. Children were tested for malaria parasites using rapid diagnostic tests and were interviewed about household information, parents' education
<em>Strongyloides stercoralis</em> is associated with significant morbidity in rural Cambodia, including stunting in children (Publications)
associated with S. stercoralis included gastrointestinal and dermatological symptoms unrelated to parasite load, and long-term chronic effects when associated with malnutrition. The combination of high
Validation of <em>Plasmodium falciparum</em> dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity (Publications)
ate nucleotido-hydrolase (dUTPase) is responsible for the hydrolysis of dUTP to dUMP within the parasite and has been proposed as an essential step in pyrimidine metabolism by providing dUMP for thymidylate
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing (Publications)
Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies. Benzoxabo
Preparation of sesquiterpene lactone-loaded PLA nanoparticles and evaluation of their antitrypanosomal activity (Publications)
advantages offered by these systems, such as targeted delivery of the drug to the place of action (cell, parasite, etc), sustained release of the drug, increased bioavailability, reduced drug dosage, and reduction
Safety and pharmacokinetics of praziquantel in european pond turtles (<em>Emys orbicularis</em>) (Publications)
endangered European pond turtle (EPT; Emys orbicularis) in Switzerland. The endogenous life cycle of the parasite often leads to systemic inflammatory reactions, thrombosis, and death. Praziquantel (PZQ) is the
Emergence of FY*A(null) in a <em>Plasmodium vivax</em>-endemic region of Papua New Guinea (Publications)
genetic polymorphisms of this nature are common in malarious regions, and all four human malaria parasites are holoendemic below 1500 meters in PNG. At this elevation, a prominent condition characterizing
Efficacy, safety, and dose of pafuramidine, a new oral drug for treatment of first stage sleeping sickness, in a phase 2a clinical study and phase 2b... (Publications)
BACKGROUND: Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death.
Community perceptions of health and rodent-borne diseases along the Inter-Oceanic Highway in Madre de Dios, Peru (Publications)
reservoirs for up to 50 % of emerging zoonotic pathogens, including a host of viruses, bacteria, and parasites. As part of a larger study involving both human and animal research, this study serves to obtain
