Preparation of sesquiterpene lactone-loaded PLA nanoparticles and evaluation of their antitrypanosomal activity (Publications)
advantages offered by these systems, such as targeted delivery of the drug to the place of action (cell, parasite, etc), sustained release of the drug, increased bioavailability, reduced drug dosage, and reduction
Safety and pharmacokinetics of praziquantel in European pond turtles (<em>Emys orbicularis</em>) (Publications)
endangered European pond turtle (EPT; Emys orbicularis) in Switzerland. The endogenous life cycle of the parasite often leads to systemic inflammatory reactions, thrombosis, and death. Praziquantel (PZQ) is the
Mathematical modelling to examine disease, control measures, vaccine interactions and resistance to guide public health and disease elimination... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/mathematical-modelling-to-examine-disease-control-measures-vaccine-interactions-and-resistance-to-guide-public-health-and-disease-elimination-strategies
policies and vaccine roll-out plans over the coming years. We will build and calibrate detailed parasite models, mosquito-to-human transmission models and adapt individual-level models for malaria. We
Indoor residual spraying for preventing malaria (Publications)
ical inoculation rate (EIR) > 1): In one RCT in Tanzania IRS reduced re-infection with malaria parasites detected by active surveillance in children following treatment; protective efficacy (PE) 54%. In [...] malaria prevalence for any infection: PE 76% in Pakistan; PE 28% in India. When looking separately by parasite species, for P. falciparum there was a PE of 92% in Pakistan and 34% in India; for P. vivax there
World Malaria Day 2024: Work together and accelerate the fight! (Page)
https://www.swisstph.ch/en/impact-stories/world-malaria-day-2024-work-together-and-accelerate-the-fight
Griffith University’s Institute for Glycomics , shed light on how the most deadly of the malaria parasites, Plasmodium falciparum , invades human blood cells. The researchers discovered that a sugar called [...] identified a specific receptor-binding site on the P. falciparum protein, which, in turn, can impede parasite growth. These findings have important ramifications and offer an attractive target for malaria vaccine
Diagnostic en parasitologie médicale | Swiss TPH Short Courses (Page)
https://www.swisstph.ch/en/study-with-us/postgraduate/diagnostic-en-parasitologie-medicale
méthodes de détection et des aspects cliniques de ces parasites tropicaux. L'un des points forts est l'observation de spécimens microscopiques et de parasites vivants. Ces cours d'une journée se concentrent
Indoor residual spraying for preventing malaria (Publications)
ical inoculation rate (EIR) > 1): In one RCT in Tanzania IRS reduced re-infection with malaria parasites detected by active surveillance in children following treatment; protective efficacy (PE) 54%. In [...] malaria prevalence for any infection: PE 76% in Pakistan; PE 28% in India. When looking separately by parasite species, for P. falciparum there was a PE of 92% in Pakistan and 34% in India; for P. vivax there
Elimination on the Horizon: Prevalence of Schistosomiasis, a Neglected Tropical Disease, Decreases by Nearly 60% (News)
https://www.swisstph.ch/en/news/news-detail/news/elimination-on-the-horizon-prevalence-of-schistosomiasis-a-neglected-tropical-disease-decreases-by-nearly-60
Schistosomiasis is a parasitic worm infection that continues to be a major public health problem, particularly in sub-Saharan Africa. Over the past 20 years, control efforts against this neglected tropical [...] developing new diagnostic tools, screening of new substances for their efficacy and safety against parasitic worms and supporting countries in building their control programmes. Pediatric Praziquantel Consortium
“It is a privilege to be able to bring science to the bedside” (Page)
https://www.swisstph.ch/en/impact-stories/it-is-a-privilege-to-be-able-to-bring-science-to-the-bedside
belong to a novel class of antimalarial compounds that target both the blood and liver stages of the parasite life cycle. The compound is currently being evaluated in several countries across Africa in children [...] standard of care for treating malaria and remain very effective. However, we are seeing an increase in parasite partial resistance to artemisinin. In addition, patient adherence remains an issue particularly [...] tion. In the field of malaria alone, I have over 200 colleagues...
Understanding drug exposure and <em>Trichuris trichiura</em> cure rates: a pharmacometric approach for albendazole-ivermectin co-medication in... (Publications)
albendazole sulfoxide and albendazole sulfone. Polymorphisms in drug-metabolizing enzymes and host-parasite interaction may explain this result. Difference in drug exposure did not explain the disparate efficacy
