Early whole blood transcriptional responses to radiation-attenuated <em>Plasmodium falciparum</em> sporozoite vaccination in malaria naive and malaria... (Publications)
across malaria-naive adult participants (IMRAS) and malaria-experienced adult participants (BSPZV1). Parasite dose and method of delivery differed between trials, and immunization regimens were designed to
Leveraging mathematical models of disease dynamics and machine learning to improve development of novel malaria interventions (Publications)
deployments per year are needed to increase prevalence reduction. We show that interventions on multiple parasite or vector targets, as well as combinations the new interventions with drug treatment, lead to s
Quality assurance of rapid diagnostic tests for malaria in routine patient care in rural Tanzania (Publications)
85.7-96.5%) and specificity was 73.5% (range 50.0-84.3%). Sensitivity increased with increasing parasite density. Successful implementation of RDTs was achieved in peripheral health facilities with adequate
Fast<em> in vitro</em> methods to determine the speed of action and the stage-specificity of anti-malarials in <em>Plasmodium falciparum</em> (Publications)
ratio between parasitaemia at the onset of drug treatment and after one intra-erythrocytic cycle (parasite reduction ratio, PRR). Both parameters are needed to determine in vitro killing rates of anti-malarial
History of malaria control in Tajikistan and rapid malaria appraisal in an agro-ecological setting (Publications)
ponds were the most important Anopheles habitats. CONCLUSION: The presence of malaria vectors and parasite reservoirs, low awareness of, and protection against malaria in the face of population movements
Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) for detection of <em>Leishmania</em> DNA in buffy coat from visceral... (Publications)
isothermal (62 [degree sign]C) conditions in a heat block. For Ln-PCR, we used primers targeting the parasite's small-subunit rRNA region. RESULTS: LAMP assay was found to be positive in 68 of 75 confirmed
<em>Anopheles plumbeus</em> (Diptera: Culicidae) in Europe: a mere nuisance mosquito or potential malaria vector? (Publications)
current populations of An. plumbeus would be able to efficiently transmit Plasmodium falciparum, the parasite responsible for the most deadly form of malaria. METHODS: Anopheles plumbeus immatures were collected
Chemometric analysis of biofluids from mice experimentally infected with <em>Schistosoma mansoni</em> (Publications)
metabolism and in gut microbial activity. Our findings provide new mechanistic insight into host-parasite interactions across different compartments and identified a set of temporally robust biomarkers
A virosomal malaria peptide vaccine elicits a long-lasting sporozoite-inhibitory antibody response in a phase 1a clinical trial (Publications)
short, conformationally constrained peptide derived from P. falciparum CSP induced a long-lived parasite-inhibitory antibody response in humans. Combination with a second virosomally-formulated peptide
Prevalence and risk factors of helminths and intestinal protozoa infections among children from primary schools in western Tajikistan (Publications)
ABSTRACT: BACKGROUND: Intestinal parasitic infections represent a public health problem in Tajikistan, but epidemiological evidence is scarce. The present study aimed at assessing the extent of helminths
