Merck Open Global Health Library <em>in vitro</em> screening against <em>Schistosoma mansoni </em>identified two new substances with antischistosomal... (Publications)
BACKGROUND: Schistosomiasis, which is caused by the parasite Schistosoma mansoni as well as other species of the trematode genus Schistosoma, leads to chronic inflammation and finally to liver fibrosis
Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections (Publications)
polygyrus mouse model, respectively. CONCLUSION: Drug screening on the larval stages of intestinal parasitic nematodes is feasible using small libraries and important given the empty drug discovery and development
Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar (Publications)
years. Additional distribution of LLINs in early 2006 resulted in a 10-fold reduction of malaria parasite prevalence. The results indicate that the Millennium Development Goals of reducing mortality in
The incidence and differential seasonal patterns of <em>Plasmodium vivax </em>primary infections and relapses in a cohort of children in Papua New... (Publications)
Plasmodium vivax has the ability to relapse from dormant parasites in the liver weeks or months after inoculation, causing further blood-stage infection and potential onward transmission. Estimates of
Drug use in the management of uncomplicated malaria in public health facilities in the Democratic Republic of the Congo (Publications)
BACKGROUND: Malaria the first causes of death from parasitic infection worldwide. Interventions to reduce the burden of malaria have produced a tremendous drop in malaria morbidity and mortality. However
O-5S quantitative real-time PCR: a new diagnostic tool for laboratory confirmation of human onchocerciasis (Publications)
BACKGROUND: Onchocerciasis is a parasitic disease caused by the filarial nematode Onchocerca volvulus. In endemic areas, the diagnosis is commonly confirmed by microscopic examination of skin snip samples
Apolipoprotein L1 variant associated with increased susceptibility to trypanosome infection (Publications)
es and an ApoL1 variant, revealing important insights into innate human immunity against these parasites. Using whole-genome sequencing, we characterized an atypicalT. b. gambienseinfection in a patient
Malaria intervention scale-up in Africa: effectiveness predictions for health programme planning tools, based on dynamic transmission modelling (Publications)
settings. RESULTS: Selected (best) GLMs explained 94-97 % of variation in simulated post-intervention parasite infection prevalence, 86-97 % of variation in case incidence (three age groups, three 3-year horizons)
Molecular characterization and distribution of <em>Schistosoma</em> cercariae collected from naturally infected bulinid snails in northern and central... (Publications)
identification of schistosome species infecting intermediate host snails is important for understanding parasite transmission, schistosomiasis control and elimination. Cercariae emerging from infected snails cannot
Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain >/= 14 days): a... (Publications)
diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response
