Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells (Publications)
Cupiennin 1a, a cytolytic peptide isolated from the venom of the spider Cupiennius salei, exhibits broad membranolytic activity towards bacteria, trypanosomes, and plasmodia, as well as human blood an
Anthelmintic activity of medicinal plants used in Côte d'Ivoire for treating parasitic diseases (Publications)
Natural products play an important role in the discovery and development of new pharmaceuticals. In the present study, we assessed the anthelmintic properties of medicinal plants used in Cote d'Ivoire
Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine... (Publications)
large hydrophobic N(6)-(4-phenoxy)benzyl substitution should allow the molecules to diffuse across parasite membranes. Starting from readily available inosine, the new compounds were prepared as single isomers
<em>Trypanothione reductase</em> high-throughput screening campaign identifies novel classes of inhibitors with anti-parasitic activity (Publications)
that are drug like and display anti-parasitic activity. For one class a series of analogues have displayed a correlation between TR inhibition and anti-parasitic activity. This paper explores the process [...] classes have been developed further through different combinations of preliminary SAR probing, anti-parasitic, cytotoxicity, and assessment of their chemical and in vitro metabolic properties. This has led
Towards a Post-Donation Era in Parasitic Worm Control (Page)
https://www.swisstph.ch/en/impact-stories/towards-a-post-donation-era-in-parasitic-worm-control
specific parasitic worm infection in a given region. Move beyond reliance on broad-spectrum treatments like albendazole or mebendazole, which can have a sub-optimal effect against some parasite species [...] approaches to parasitic worm treatment is over. As Aristotle’s quote reminds us, treating unequal things equally can perpetuate inequality. To further reduce the global burden of parasitic worms, we must [...] the large-scale deworming campaigns have made significant strides in reducing...