Frédéric Tripet (People)
https://www.swisstph.ch/en/staff/profile/people/frederic-tripet
facilities at the Malaria Research and Training center in Mali, West Africa. From 2018-2023 F. Tripet was a partner and field entomology technical coordinator on the Target Malaria consortium, a not- [...] and focus on the applied integrative biology of mosquitoes that transmit human pathogens, such as Malaria, Dengue, Chikungunya and Zika, with a view on developing novel tools for their control. From 2008 [...] that aims to develop new approaches to sterile male mosquito releases to reduce the...
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment and prevention of disease transmission (Publications)
Renewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life-cycle. We have previously reported the [...] that have activity in the prevention and treatment of blood stage infection in a mouse model of malaria. Consistent with the activity profile of this series the clinical candidate KAF156 shows blood s [...] drug-sensitive and drug-resistant strains as well as potent therapeutic activity in...
Contribution of dengue fever to the burden of acute febrile illnesses in Papua New Guinea: an age-specific prospective study (Publications)
were enrolled, and 317 patients with a negative rapid diagnostic test (RDT) for malaria were tested for dengue. Malaria was confirmed in 52% (301/578, 95% confidence interval [CI] = 48-56%), DF was diagnosed [...] Abstract. Malaria is a major contributor to the burden of febrile illnesses in Papua New Guinea (PNG). Dengue fever (DF) is likely to contribute; however, its epidemiology in PNG is poorly understood. [...] diagnosed in 8% (46/578, 95% CI = 6-10%), and 40% (95% CI = 36-44%) had neither...
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment and prevention of disease transmission (Publications)
Renewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life-cycle. We have previously reported the [...] that have activity in the prevention and treatment of blood stage infection in a mouse model of malaria. Consistent with the activity profile of this series the clinical candidate KAF156 shows blood s [...] drug-sensitive and drug-resistant strains as well as potent therapeutic activity in...
Contribution of dengue fever to the burden of acute febrile illnesses in Papua New Guinea: an age-specific prospective study (Publications)
were enrolled, and 317 patients with a negative rapid diagnostic test (RDT) for malaria were tested for dengue. Malaria was confirmed in 52% (301/578, 95% confidence interval [CI] = 48-56%), DF was diagnosed [...] Abstract. Malaria is a major contributor to the burden of febrile illnesses in Papua New Guinea (PNG). Dengue fever (DF) is likely to contribute; however, its epidemiology in PNG is poorly understood. [...] diagnosed in 8% (46/578, 95% CI = 6-10%), and 40% (95% CI = 36-44%) had neither...
Medicines Implementation Research | Research at Swiss TPH (Page)
https://www.swisstph.ch/en/about/med/miru
Treatment of severe Malaria The serious disease malaria is a major burden in tropical and subtropical countries. Although great efforts have been made to control and eliminate malaria, more than 400,000 [...] Rectal Artesunate for Malaria Many children suffering from severe malaria live in poor rural communities with no access to health care. Where parenteral treatment of severe malaria is not available, the [...] Artesunate to Treat Severe Malaria The serious disease malaria is a high burden in...
The use of the polymerase chain reaction for more sensitive detection of <em>Plasmodium falciparum</em> (Publications)
positive for P. vivax and P. malariae an underlying P. falciparum infection remained undetected by microscopy. The introduction of PCR has opened up new possibilities in malaria diagnosis and research. [...] The prevalence of Plasmodium falciparum in children and adults living in a malaria-endemic area in Papua New Guinea was determined by microscopy and by polymerase chain reaction (PCR). The sensitivity
The use of the polymerase chain reaction for more sensitive detection of <em>Plasmodium falciparum</em> (Publications)
positive for P. vivax and P. malariae an underlying P. falciparum infection remained undetected by microscopy. The introduction of PCR has opened up new possibilities in malaria diagnosis and research. [...] The prevalence of Plasmodium falciparum in children and adults living in a malaria-endemic area in Papua New Guinea was determined by microscopy and by polymerase chain reaction (PCR). The sensitivity
Using a mobile nanopore sequencing lab for end-to-end genomic surveillance of <em>Plasmodium falciparum</em>: a feasibility study (Publications)
Genomic epidemiology holds promise for malaria control and elimination efforts, for example by informing on Plasmodium falciparum genetic diversity and prevalence of mutations conferring anti-malarial [...] drug resistance. Limited sequencing infrastructure in many malaria-endemic areas prevents the rapid generation of genomic data. To address these issues, we developed and validated assays for P. falciparum [...] resistance markers. We developed a bioinformatics workflow that allows genotyping...
Withholding antimalarials in febrile children who have a negative result for a rapid diagnostic test (Publications)
admitted to the hospital subsequently, all with negative results for malaria tests upon admission. Two of them died, of causes other than malaria. Conclusions. Not giving antimalarial drugs in febrile children [...] Background. The availability of a rapid diagnostic test for malaria (RDTm) allows accurate diagnosis at all levels of health facilities. The objective of the present study was to evaluate the safety of [...] prospective 2-arm longitudinal study in areas of Tanzania that are...
