The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
Malaria parasites undergo a complex life cycle in the human host and the mosquito vector. The ApiAP2 family of DNA-binding proteins plays a dominant role in parasite development and life cycle progression [...] maintenance. In summary, our findings reveal PfAP2-HC as a core component of heterochromatin in malaria parasites and identify unexpected properties and substantial functional divergence among the members of the
Anthropozoonotic parasites circulating in synanthropic and pacific colonies of South American sea lions (<em>Otaria flavescens</em>): non-invasive... (Publications)
revealed the presence of nine different parasite taxa in individual fecal samples, including two protozoan (Cryptosporidium spp. and Giardia spp.) and seven metazoan parasites (Anisakidae gen. spp., Diphyllobothriidae [...] South American sea lions was conducted, revealing reports of at least 50 protozoan and metazoan parasite taxa including findings of the current study. Thereby, at least 25 of reported taxa (50%) have been [...] applicability in the field of marine mammal parasitology,...
A cross-sectional survey on parasitic infections in schoolchildren in a rural Tanzanian community (Publications)
lymphatic filariasis were rare. Having a latrine inside the house was associated with a lower odds of parasite infections (odds ratio (OR) 0.51, 95% confidence interval (CI) 0.27-0.96, p=0.04). Children from [...] the 1980s, there seems to have been a substantial reduction in the prevalence and intensity of parasitic infections, except for T. trichiura, which showed a similar prevalence. Our data suggest that the [...] disease control programmes improved children's health markedly. However,...
Core components, concepts and strategies for parasitic and vector-borne disease elimination with a focus on schistosomiasis: a landscape analysis (Publications)
, to controversy around adequate intervention strategies. We conducted a landscape analysis on parasitic and vector-borne disease elimination approaches with the aim to identify evidence-based strategies
A recombinant blood-stage malaria vaccine reduces<em> Plasmodium falciparum</em> density and exerts selective pressure on parasite populations in a... (Publications)
confidence limits: 13%, 84%) reduction in parasite density in children not pretreated with sulfadoxine-pyrimethamine. Vaccinees had a lower prevalence of parasites carrying the MSP2-3D7 allelic form (cor [...] with FC27-type parasites. These results demonstrate functional activity of Combination B against P. falciparum in individuals with previous malaria exposure. The specific effects on parasites with particular [...] least in part, accounted for the activity. The vaccine-induced selection...
Isothermal microcalorimetry accurately detects bacteria, tumorous microtissues, and parasitic worms in a label-free well-plate assay (Publications)
cancer research, diagnostics and development of new antitumor drugs. For parasitic worms, the technique allows assessment of the parasite survival using motor and metabolic activities even with a single worm
Association between allergic sensitization and intestinal parasite infection in schoolchildren in Gqeberha, South Africa (Publications)
BACKGROUND: Inconsistent data exist regarding the influence of parasitic infection on the prevalence of allergic sensitization and disorders. OBJECTIVE: To investigate the impact of geohelminth and protozoan [...] recruited in June 2016 and screened for reactivity to common allergens by skin prick tests and for parasitic infections by stool tests. Additionally, questionnaires were completed to record allergic symptoms [...] of study participants. Mixed logistic regression analyses revealed...
Intestinal parasites in segregated minority communities of Slovakia: results from a cross-sectional survey in children (Publications)
revealed a high prevalence of parasitic infections. There is a paucity of recent data, and hence, we designed a study to investigate the current status of intestinal parasitic infections in this population
3D imaging of undissected optically cleared <em>Anopheles stephensi </em>mosquitoes and midguts infected with <em>Plasmodium</em> parasites (Publications)
life-threatening disease, caused by Apicomplexan parasites of the Plasmodium genus. The Anopheles mosquito is necessary for the sexual replication of these parasites and for their transmission to vertebrate hosts [...] hosts, including humans. Imaging of the parasite within the insect vector has been attempted using multiple microscopy methods, most of which are hampered by the presence of the light scattering opaque [...] from OPT imaging show detailed features of the mosquito anatomy and...
