Residual antimalarials in malaria patients from Tanzania - implications on drug efficacy assessment and spread of parasite resistance (Publications)
BACKGROUND: Repeated antimalarial treatment for febrile episodes and self-treatment are common in malaria-endemic areas. The intake of antimalarials prior to participating in an in vivo study may alte
The activities of current antimalarial drugs on the life cycle stages of <em>Plasmodium</em>: a comparative study with human and rodent parasites (Publications)
measure activity of antimalarials against all life stages of malaria parasites, using a diverse set of human and nonhuman parasite species, including male gamete production (exflagellation) in Plasmodium
Multi-host model-based identification of <em>Armillifer agkistrodontis</em> (Pentastomida), a new zoonotic parasite from China (Publications)
BACKGROUND: Pentastomiasis is a rare parasitic infection of humans. Pentastomids are dioecious obligate parasites requiring multiple hosts to complete their lifecycle. Despite their worm-like appearance [...] and snakes (Agkistrodon acutus and Python molurus) as definitive hosts. Different stages of the parasite, including eggs, larvae and adults, were isolated and examined morphologically using light and electron
Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites: <em>Trichuris muris</em>,... (Publications)
of the benzimidazole drugs, the mainstay of preventative chemotherapy for whipworm, together with parasite drug resistance, mean that current approaches may not be able to eliminate morbidity from trichuriasis [...] (DBQs) with anthelmintic activity. We investigated the activity of these compounds against other parasitic nematodes, identifying DHB compounds with activity against Brugia malayi and Heligmosomoides polygyrus [...] polygyrus. We also demonstrated activity of DHB compounds against...
Host cells participate in the in vitro effects of new-generation diamidine-analogues against tachyzoites of the intracellular apicomplexan parasites... (Publications)
dicationic diamidine-derivatives against the proliferative tachyzoite stages of the apicomplexan parasites Neospora caninum and Toxoplasma gondii were investigated. Four compounds (DB811, DB786, DB750 and [...] Electron microscopy of N. caninum-infected HFF cultures revealed distinct alterations and damage of parasite ultrastructure upon drug treatment, while host cells remained unaffected. To exert true parasiticidal [...] tachyzoites and subsequent culture in the absence of DB750, resulted in...
Inhibiting activities of the secondary metabolites of <em>Phlomis brunneogaleata</em> against parasitic protozoa and plasmodial enoyl-ACP reductase, a... (Publications)
Anti-plasmodial activity-guided fractionation of Phlomis brunneogaleata (Lamiaceae) led to the isolation of two new metabolites, the iridoid glycoside, brunneogaleatoside and a new pyrrolidinium deriv
