Intravenous artesunate reduces parasite clearance time, duration of intensive care and hospital treatment in patients with severe malaria in Europe:... (Publications)
database was analyzed to compare outcomes of artesunate vs. quinine treatment. Artesunate reduced parasite clearance time, duration of ICU- and hospital treatment in European patients with imported severe
Impact of malaria pre-exposure on anti-parasite cellular and humoral immune responses after controlled human malaria infection (Publications)
To understand the effect of previous malaria exposure on anti-parasite immune responses is important for developing successful immunization strategies. Controlled human malaria infections (CHMI) using [...] s from different transmission settings and genetic backgrounds. In this study, we compared anti-parasite humoral and cellular immune responses in two cohorts of malaria-naive Dutch volunteers and Tanzanians [...] resembled the malaria-naive Dutch cohort. Positive Pf serology at baseline was...
Gift from nature: cyclomarin a kills mycobacteria and malaria parasites by distinct modes of action (Publications)
Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. We have conducted a s
Health-related quality of life among school children with parasitic infections: findings from a national cross-sectional survey in Côte d'Ivoire (Publications)
BACKGROUND: Parasitic infections are still of considerable public health relevance, notably among children in low- and middle-income countries. Measures to assess the magnitude of ill-health in infected [...] regression models were applied to identify significant associations between HrQoL and children's parasitic infection and clinical status. PRINCIPAL FINDINGS: Parasitological examination of 4,848 children [...] self-rated HrQoL on a scale from 0 to 100, whereas no significant negative...
Comparison of detection methods to estimate asexual <em>Plasmodium falciparum</em> parasite prevalence and gametocyte carriage in a community survey... (Publications)
BACKGROUND: The use of molecular techniques to detect malaria parasites has been advocated to improve the accuracy of parasite prevalence estimates, especially in moderate to low endemic settings. Molecular [...] via a community survey in Tanzania, using polymerase chain reaction (PCR) to detect P. falciparum parasites and gametocytes. METHODS: Three hundred and thirty individuals of all ages from the Kilombero and [...] (Tanzania) were enrolled in a cross-sectional survey. Finger prick blood...
Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective and efficacious antitrypanosomal strategy (Publications)
higher affinity for parasite over mammalian nucleobase transporters and does not show cross-resistance with current first line drugs. Once selectively accumulated inside the parasite, the prodrug releases [...] options. We designed methyltriazenyl purine prodrugs to be rapidly and selectively internalized by the parasite, after which they disintegrate into a non-toxic, naturally occurring purine nucleobase, a simple [...] genotoxicity, hepatotoxicity and cytotoxicity against mammalian cells...
