Inhibitors of adenosine consuming parasites through polymer-assisted solution phase synthesis of lipophilic 5'-amido-5'-deoxyadenosine... (Publications)
large hydrophobic N(6)-(4-phenoxy)benzyl substitution should allow the molecules to diffuse across parasite membranes. Starting from readily available inosine, the new compounds were prepared as single isomers
<em>Trypanothione reductase</em> high-throughput screening campaign identifies novel classes of inhibitors with anti-parasitic activity (Publications)
that are drug like and display anti-parasitic activity. For one class a series of analogues have displayed a correlation between TR inhibition and anti-parasitic activity. This paper explores the process [...] classes have been developed further through different combinations of preliminary SAR probing, anti-parasitic, cytotoxicity, and assessment of their chemical and in vitro metabolic properties. This has led
Anthelmintic activity of medicinal plants used in Côte d'Ivoire for treating parasitic diseases (Publications)
Natural products play an important role in the discovery and development of new pharmaceuticals. In the present study, we assessed the anthelmintic properties of medicinal plants used in Cote d'Ivoire
The role of parasitic infections in atopic diseases in rural schoolchildren (Publications)
the farming environment has a protective effect as regards allergic diseases. Exposure to animal parasites, particularly helminth infections, is common in the farming environment. However, the role of helminths [...] this population. Although farmers' children had increased antibody levels reactive to helminth parasites indicating exposure, this did not explain the protective effect of farming against atopic diseases
Estimation of infection and recovery rates for highly polymorphic parasites when detectability is imperfect, using hidden Markov models (Publications)
model is proposed for estimating parasitic infection dynamics for highly polymorphic parasites when detectability of the parasite using standard tests is imperfect. The parasite dynamics are modelled as a [...] detection or failure to detect a parasitic genotype. This is assumed to be conditionally independent given the hidden process, that is, the underlying true presence of the parasite, which evolves according to [...] host and bed net use as covariates. This analysis confirmed that the...
