Helminth parasites and hypobiosis of nematodes in N'Dama cattle during the dry season in The Gambia (Publications)
Three series of necropsies of cattle were performed, corresponding to early dry season, approximately 1 month after the last rains (November, n = 6), mid dry season (February, n = 6) and end dry seaso
Less common parasitic infections in Southeast Asia that can produce outbreaks (Publications)
foodstuff and wildlife in parts of Southeast Asia have repeatedly led to outbreaks due to rare parasitic infections. Trichinellosis, capillariasis and angiostrongyliasis are the three prime examples of [...] and commonly leading to inappropriate treatment and control. Angiostrongyliasis is an emerging parasitic infection with a number of significant outbreaks reported recently, particularly in the People's [...] surveillance to adequately tackle trichinellosis, capillariasis, angiostrongyliasis...
Efficacy of killed whole-parasite vaccines in the prevention of leishmaniasis: a meta-analysis (Publications)
in some of the controlled trials conducted with "first-generation" whole, inactivated Leishmania parasite vaccines, convincing evidence of protection was lacking. After reviewing all previously published [...] revealed by considering the results of all trials together. The findings indicate that the whole-parasite vaccine candidates tested do not confer significant protection against human leishmaniasis
Epigenetic memory takes center stage in the survival strategy of malaria parasites (Publications)
Malaria parasites run through a complex life cycle in the vertebrate host and mosquito vector. This not only requires tightly controlled mechanisms to govern stage-specific gene expression but also ne [...] -omics approaches and targeted functional studies highlighted that Plasmodium falciparum blood stage parasites use heterochromatin-based gene silencing as a unifying strategy for clonally variant expression [...] conversion and discuss the relevance of this strategy for the survival and...
Identification and characterization of a conserved, stage-specific gene product of <em>Plasmodium falciparum</em> recognized by parasite growth... (Publications)
Inclusion of certain anti-D13 MAbs into in vitro cultures of blood stage parasites resulted in considerable reduction in parasite growth. The N'-terminal domain encompassing 158 amino acids is 94 and 95% [...] falciparum, designated D13, that is stage-specifically expressed in asexual blood stages of the parasite. The predicted open reading frame (ORF) D13 contains 863 amino acids with a calculated molecular [...] composed of pentapeptide motives. Northern blot analysis with lysates of...
Novel functionalized melamine-based nitroheterocycles: synthesis and activity against trypanosomatid parasites (Publications)
Human African trypanosomiasis (HAT), caused by the protozoan parasite Trypanosoma brucei spp., is a major health problem in sub-Saharan Africa. New drugs are urgently required for the disease. Selective