<em>"Koko et les lunettes magiques"</em>: an educational entertainment tool to prevent parasitic worms and diarrheal diseases in Côte d'Ivoire (Publications)
food were the main causes of parasitic worm infections. Abdominal pain, diarrhea, lack of appetite, failure to grow, and general fatigue were mentioned as symptoms of parasitic worm infections. Most of the [...] conducted to assess the knowledge, attitudes, practices, and beliefs of school-aged children regarding parasitic worm infections and hygiene, to identify key health messages to be included in an animated cartoon [...] children knew that they should go to the hospital for treatment if...
Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite <em>Plasmodium falciparum</em> (Publications)
compensatory response, linking parasite metabolism to the activation of sexual-stage-specific transcription and gametocyte formation. Our results reveal that malaria parasites can sense and process host-derived [...] efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes, are infective to the mosquito vector. Gametocyte production rates vary depending [...] host-derived lipid lysophosphatidylcholine (LysoPC) controls P....
Screening of the 'Open Scaffolds' collection from<em> Compounds Australia</em> identifies a new chemical entity with anthelmintic activities against... (Publications)
of novel anthelmintic classes is essential to sustain the control of socioeconomically important parasitic worms of humans and animals. With the aim of offering novel, lead-like scaffolds for drug discovery [...] = 0.31-12.5 muM) and caused considerable cuticular damage to L4s in vitro. When tested on other parasitic nematodes in vitro, SN00797439 was shown to inhibit (IC50 = 3-50 muM) adults of Ancylostoma ceylanicum [...] Overall, these results show that SN00797439 acts against genetically...
School children's intestinal parasite and nutritional status 1 year after complementary school garden, nutrition, water, sanitation, and hygiene... (Publications)
determine whether complementary school garden, nutrition, and WASH interventions reduce intestinal parasites and improve school children's nutritional status in two regions of Burkina Faso. A cluster-randomized [...] impact of the interventions, controlling for baseline characteristics. The prevalence of intestinal parasitic infections decreased both in intervention and control schools, but the decrease was significantly [...] delivered through the school platform improved several child...
Synthesis of 1,2,3-triazole-methyl-menadione derivatives: evaluation of electrochemical and antiparasitic properties against two blood-dwelling... (Publications)
their electrochemical properties and antiparasitic efficacies against two human blood-dwelling parasites Plasmodium falciparum and Schistosoma mansoni. Using copper-catalyzed azide-alkyne cycloaddition [...] potencies, while no significant activity was observed for the same series against P. falciparum parasites. Electrochemical and 'benzylic' oxidation studies confirmed that the active 'benzoyl' metabolite
Regioselective synthesis of potential non-quinonoid prodrugs of plasmodione: antiparasitic properties against two hemoglobin-feeding parasites and... (Publications)
be revealed if the molecule undergoes an oxidation of the angular methyl, e.g., in blood-feeding parasites that digest hemoglobin from the host, the antimalarial and the antischistosomal properties of both
Risk of intestinal parasitic infections in people with different exposures to wastewater and fecal sludge in Kampala, Uganda: a cross-rectional study (Publications)
infection with intestinal parasites and self-reported health outcomes, stratified by population group. PRINCIPAL FINDINGS: The highest point-prevalence of intestinal parasite infections was found in urban [...] low- and middle-income countries. We assessed the point-prevalence and risk factors of intestinal parasite infections in people with different exposures to wastewater and fecal sludge in Kampala, Uganda [...] was administered to determine self-reported signs and symptoms, and risk factors...
GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing (Publications)
Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each replication cycle, some parasites differentiate into gametocytes, the only forms able to infect the mosquito vector [...] matin protein 1 (HP1)-dependent silencing of ap2-g prevents sexual conversion in proliferating parasites. In this study, we identified Plasmodium falciparum gametocyte development 1 (GDV1) as an upstream
