Malaria and the 'last' parasite: how can technology help? (Publications)
eliminating malaria has saved millions of lives, but also creates new challenges in detecting the 'last parasite'. Effective and accurate detection of malaria infections, both in symptomatic and asymptomatic
Case report: management of dead intraocular helminth parasites in asymptomatic patients (Publications)
finding of a dead intraocular helminth parasite on ophthalmological routine examination. Because the patients were asymptomatic and the intraocular helminth parasites dead without noted pathology present [...] two years was uneventful and showed no complications. We conclude that dead intraocular helminth parasites in asymptomatic patients without apparent pathology do not require surgical removal.
Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases (Publications)
Progress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. However, there is a risk of re-emergence if the factors fueling transmission are n
Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development (Publications)
different modes of action, to assess host-parasite interactions in two preclinical drug testing systems of murine parasite P. berghei in mice, and human parasite P. falciparum in immune-deficient mice. We [...] uninvestigated parasite behavior such as dormancy influences parasite recrudescence following non-curative treatment and requires further investigation. Taken together, host-parasite interactions should [...] translation of drug efficacy and host-parasite dynamics between preclinical...
Secreted microRNA data from the parasitic filarial nematode <em>Acanthocheilonema viteae</em> (Publications)
iptional level. The helminth Acanthocheilonema viteae serves as model organism for research on parasitic filarial nematodes. Total RNA secreted or excreted in vitro by 1500 adult female and male A. viteae
Water-related parasitic diseases in China (Publications)
considerable burden due to parasitic diseases in certain areas and populations across the country. In this review, we demonstrated three aspects of ten major water-related parasitic diseases, i.e., the biology [...] Water-related parasitic diseases are directly dependent on water bodies for their spread or as a habitat for indispensable intermediate or final hosts. Along with socioeconomic development and improvement
Diagnostics are central for a truly holistic approach against intestinal parasitic diseases (Publications)
on the central role of diagnostics for a truly holistic approach against gastrointestinal (GI) parasitic diseases. This article was motivated by a recent review in the International Journal of Infectious
In silico ionomics segregates parasitic from free-living eukaryotes (Publications)
hand, from free-living species and facultative parasites (n=14) on the other hand. This surprising finding indicates strong convergent evolution of the parasites regarding the acquisition and homeostasis of [...] s of iron and other transition metals, as the most informative for distinguishing the obligate parasites. Thus in silico ionomics further underscores the importance of iron in infection biology and suggests [...] access to host sources of nitrogen and transition metals to be selective...
Bromopyrrole alkaloids as lead compounds against protozoan parasites (Publications)
marine sponges belonging to Axinella and Agelas genera have been screened in vitro against four parasitic protozoa, i.e., two Trypanosoma species (T. brucei rhodesiense and T. cruzi), Leishmania donovani
