Searched for parasites.

1. Inhibitors of PEX14 disrupt protein import into glycosomes and kill <em>Trypanosoma</em> parasites (Publications)

   Inhibitors of PEX14 disrupt protein import into glycosomes and kill <em>Trypanosoma</em> parasites

   Relevance:

   The parasitic protists of the Trypanosoma genus infect humans and domestic mammals, causing severe mortality and huge economic losses. The most threatening trypanosomiasis is Chagas disease, affecting [...] results in mislocalization of glycosomal enzymes, causing metabolic catastrophe, and it kills the parasite. High-resolution x-ray structures and nuclear magnetic resonance data enabled the efficient design

2. Intestinal parasite infections and associated risk factors in communities exposed to wastewater in urban and peri-urban transition zones in Hanoi,... (Publications)

   Intestinal parasite infections and associated risk factors in communities exposed to wastewater in urban and peri-urban transition zones in Hanoi, Vietnam

   Relevance:

   settings, little is known about the extent of intestinal parasite infections. We assessed the point-prevalence and risk factors of intestinal parasite infections in population groups differently exposed to [...] BACKGROUND: Infections with intestinal parasites (helminths and intestinal protozoa) are endemic in Southeast Asia and inappropriate management and reuse of wastewater might exacerbate the risk of human [...] total of 681 individuals had complete data records. Highest point-prevalence...

3. Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA (Publications)

   Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA

   Relevance:

   c MYB-type domain. Here, we identified the telomere repeat-binding protein PfTRZ in the malaria parasite Plasmodium falciparum, a member of the Alveolate phylum for which TRFs have not been described so

4. Antimalarial pyrido[1,2-a]benzimidazoles: lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics, and <em>in... (Publications)

   Antimalarial pyrido[1,2-a]benzimidazoles: lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics, and <em>in vivo</em> oral efficacy in a mouse model

   Relevance:

   with improved in vivo oral efficacy in the P. berghei mouse model and additional activity against parasite liver and gametocyte stages, making them potential candidates for preclinical development. Inhibition

5. Sensitive and accurate quantification of human malaria parasites using droplet digital PCR (ddPCR) (Publications)

   Sensitive and accurate quantification of human malaria parasites using droplet digital PCR (ddPCR)

   Relevance:

   Accurate quantification of parasite density in the human host is essential for understanding the biology and pathology of malaria. Semi-quantitative molecular methods are widely applied, but the need for [...] for an external standard curve makes it difficult to compare parasite density estimates across studies. Droplet digital PCR (ddPCR) allows direct quantification without the need for a standard curve. ddPCR [...] well as in asymptomatic samples. ddPCR yielded highly reproducible...

6. Prevalence of intestinal parasitic infections and associated risk factors among schoolchildren in the Plateau Central and Centre-Ouest regions of... (Publications)

   Prevalence of intestinal parasitic infections and associated risk factors among schoolchildren in the Plateau Central and Centre-Ouest regions of Burkina Faso

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7. Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across... (Publications)

   Identification of a potential antimalarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life cycle

   Relevance:

   identification of highly potent compounds against the blood life-cycle stage of the human malaria parasite Plasmodium falciparum. Several compounds displayed high in vivo efficacy in two different mouse [...] have good pharmacokinetics and additionally very potent activity against the liver and gametocyte parasite life-cycle stages.

8. Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites (Publications)

   Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites

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9. Parasites de l’appareil gastro-intestinal (Publications)

   Parasites de l’appareil gastro-intestinal

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10. Human migration and the spread of malaria parasites to the New World (Publications)

    Human migration and the spread of malaria parasites to the New World

    Relevance:

    We examined the mitogenomes of a large global collection of human malaria parasites to explore how and when Plasmodium falciparum and P. vivax entered the Americas. We found evidence of a significant [...] contribution of African and South Asian lineages to present-day New World malaria parasites with additional P. vivax lineages appearing to originate from Melanesia that were putatively carried by the [...] carriers of P. falciparum mitochondrial lineages into the Americas after the conquest,...