Searched for parasites.

1. Development of a focused library of triazole-linked privileged-structure-based conjugates leading to the discovery of novel phenotypic hits against... (Publications)

   Development of a focused library of triazole-linked privileged-structure-based conjugates leading to the discovery of novel phenotypic hits against protozoan parasitic infections

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   biphenyl, and phenylpiperazine scaffolds. The resulting 18 compounds were then tested against seven parasite strains, and counter-screened for selectivity against two mammalian cell lines. In parallel, hERG

2. Epidemiology of intestinal parasite infections in three departments of south-central Côte d’Ivoire before the implementation of a cluster-randomised... (Publications)

   Epidemiology of intestinal parasite infections in three departments of south-central Côte d’Ivoire before the implementation of a cluster-randomised trial

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3. Author correction: The temporal dynamics and infectiousness of subpatent<em> Plasmodium falciparum </em>infections in relation to parasite density (Publications)

   Author correction: The temporal dynamics and infectiousness of subpatent<em> Plasmodium falciparum </em>infections in relation to parasite density

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   An amendment to this paper has been published and can be accessed via a link at the top of the paper.

4. The temporal dynamics and infectiousness of subpatent <em>Plasmodium falciparum</em> infections in relation to parasite density (Publications)

   The temporal dynamics and infectiousness of subpatent <em>Plasmodium falciparum</em> infections in relation to parasite density

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   individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that [...] infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission

5. Pyemotes ventricosus dermatitis: a serpiginous skin lesion due to a mite that parasitizes a wood-boring beetle (Publications)

   Pyemotes ventricosus dermatitis: a serpiginous skin lesion due to a mite that parasitizes a wood-boring beetle

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6. Pyrimethamine-resistant <em>Plasmodium falciparum</em> parasites among Tanzanian children: a facility-based study using the polymerase chain reaction (Publications)

   Pyrimethamine-resistant <em>Plasmodium falciparum</em> parasites among Tanzanian children: a facility-based study using the polymerase chain reaction

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   Twenty-eight percent of the examined 101 children had pyrimethamine-resistant parasites, 65% had pyrimethamine-sensitive parasites with the wild-type Ser-108 codon, and 9% had both alleles, suggesting a mixed [...] polymerase chain reaction method was used to estimate the proportion of pyrimethamine-resistant parasites in 101 children reporting with malaria at the hospital in Ifakara, a town in southern Tanzania. [...] mixed infection. None of the 21 children with clinical malaria had...

7. Regulation of sexual commitment in malaria parasites: a complex affair (Publications)

   Regulation of sexual commitment in malaria parasites: a complex affair

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   Malaria blood stage parasites commit to either one of two distinct cellular fates while developing within erythrocytes of their mammalian host: they either undergo another round of asexual replication [...] support or impair the ultimate goal of human-to-human transmission via the mosquito vector. Malaria parasites therefore evolved strategies to control investments into asexual proliferation versus gametocyte [...] control and environmental modulation of sexual commitment in the two most widely...

8. Investigating the link between nutrient sensing and gametocyte formation in the malaria parasite <em>Plasmodium falciparum</em>. (Publications)

   Investigating the link between nutrient sensing and gametocyte formation in the malaria parasite <em>Plasmodium falciparum</em>.

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9. Interactions between immunity and metabolism: contributions from the metabolic profiling of parasite-rodent models (Publications)

   Interactions between immunity and metabolism: contributions from the metabolic profiling of parasite-rodent models

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   the small-molecule level within a host organism, and specific metabolic fingerprints of several parasitic infections have been characterized by 1H NMR spectroscopy. The application of multivariate statistical

10. Metabolism of (<em>R</em>)-praziquantel versus the activation of a Parasite Transient Receptor Potential Melastatin ion channel (Publications)

    Metabolism of (<em>R</em>)-praziquantel versus the activation of a Parasite Transient Receptor Potential Melastatin ion channel

    Relevance:

    Praziquantel (PZQ) is an essential anthelmintic drug recently established to be an activator of a Transient Receptor Potential Melastatin (TRPM(PZQ) ) ion channel in trematode worms. Bioinformatic, mu