Searched for parasites.

1. Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite <em>Plasmodium falciparum</em> (Publications)

   Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite <em>Plasmodium falciparum</em>

   Relevance:

   compensatory response, linking parasite metabolism to the activation of sexual-stage-specific transcription and gametocyte formation. Our results reveal that malaria parasites can sense and process host-derived [...] efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes, are infective to the mosquito vector. Gametocyte production rates vary depending [...] host-derived lipid lysophosphatidylcholine (LysoPC) controls P....

2. Whole blood transcriptome changes following controlled human malaria infection in malaria pre-exposed volunteers correlate with parasite prepatent... (Publications)

   Whole blood transcriptome changes following controlled human malaria infection in malaria pre-exposed volunteers correlate with parasite prepatent period

   Relevance:

   signaling and erythrocyte development. Our study showed that in malaria pre-exposed volunteers, parasite prepatent period in each individual is linked to magnitude and timing of early gene expression changes

3. <em>Theileria </em>parasites subvert E2F signaling to stimulate leukocyte proliferation (Publications)

   <em>Theileria </em>parasites subvert E2F signaling to stimulate leukocyte proliferation

   Relevance:

4. Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases (Publications)

   Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases

   Relevance:

   Progress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. However, there is a risk of re-emergence if the factors fueling transmission are n

5. Secreted microRNA data from the parasitic filarial nematode <em>Acanthocheilonema viteae</em> (Publications)

   Secreted microRNA data from the parasitic filarial nematode <em>Acanthocheilonema viteae</em>

   Relevance:

   iptional level. The helminth Acanthocheilonema viteae serves as model organism for research on parasitic filarial nematodes. Total RNA secreted or excreted in vitro by 1500 adult female and male A. viteae

6. Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development (Publications)

   Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development

   Relevance:

   different modes of action, to assess host-parasite interactions in two preclinical drug testing systems of murine parasite P. berghei in mice, and human parasite P. falciparum in immune-deficient mice. We [...] uninvestigated parasite behavior such as dormancy influences parasite recrudescence following non-curative treatment and requires further investigation. Taken together, host-parasite interactions should [...] translation of drug efficacy and host-parasite dynamics between preclinical...

7. Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle (Publications)

   Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle

   Relevance:

   combination therapy (ACT) is the main treatment option for malaria, which is caused by the intracellular parasite Plasmodium. However, increased resistance to ACT highlights the importance of finding new drugs [...] master modulator of merozoite invasion and direct maturation of proteins required for invasion, parasite development, and egress. Oral administration of WM382 cured mice of P. berghei and prevented blood

8. Case report: management of dead intraocular helminth parasites in asymptomatic patients (Publications)

   Case report: management of dead intraocular helminth parasites in asymptomatic patients

   Relevance:

   finding of a dead intraocular helminth parasite on ophthalmological routine examination. Because the patients were asymptomatic and the intraocular helminth parasites dead without noted pathology present [...] two years was uneventful and showed no complications. We conclude that dead intraocular helminth parasites in asymptomatic patients without apparent pathology do not require surgical removal.

9. The temporal dynamics and infectiousness of subpatent <em>Plasmodium falciparum</em> infections in relation to parasite density (Publications)

   The temporal dynamics and infectiousness of subpatent <em>Plasmodium falciparum</em> infections in relation to parasite density

   Relevance:

   individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that [...] infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission

10. Development of a focused library of triazole-linked privileged-structure-based conjugates leading to the discovery of novel phenotypic hits against... (Publications)

    Development of a focused library of triazole-linked privileged-structure-based conjugates leading to the discovery of novel phenotypic hits against protozoan parasitic infections

    Relevance:

    biphenyl, and phenylpiperazine scaffolds. The resulting 18 compounds were then tested against seven parasite strains, and counter-screened for selectivity against two mammalian cell lines. In parallel, hERG