Triple Drug Combination Shows High Activity Against Parasitic Worm Infections (News)
https://www.swisstph.ch/en/news/20180417-triple-drug-combination
programmes." A centre of expertise in parasitic worm infections Swiss TPH is active in a broad range of activities related to research and control of parasitic worm infections. The work comprises basic [...] Current strategy not sufficient to control parasitic worm infections The current strategy of the World Health Organization (WHO) against soil-transmitted Helminthiasis - so called preventive chemotherapy
New Understanding of Parasite Biology Might Help Stop Malaria Transmission (News)
https://www.swisstph.ch/en/news/news-detail/news/new-understanding-of-parasite-biology-might-help-stop-malaria-transmission
how malaria parasites control the switch to gametocyte production is central to support the development of therapeutic interventions that could block malaria transmission. How malaria parasites turn the switch [...] (LPC). Under high LPC concentrations, parasites multiply, consuming LPC to build new membranes. When LPC concentrations drop, as they do during acute infections, parasites convert into gametocytes to secure [...] identified a parasite protein (GDV1) that plays a crucial role in...
International Experts Discuss Innovative Strategies to Tackle Parasitic Worms (News)
https://www.swisstph.ch/en/news/news-detail/news/international-experts-discuss-innovative-strategies-to-tackle-parasitic-worms
million suffer from schistosomiasis; two of the most common parasitic worm infections. They are transmitted by different species of parasitic worms in the soil or water and can result in diarrhoea, malnutrition [...] innovations in diagnostics and drugs and to discuss control strategies to interrupt transmission of parasitic worm infections. One presentation showed results from Zanzibar that demonstrate how a multifaceted [...] package can reduce prevalence of infection among school-aged...
An Animated Cartoon against Parasitic Worm Infections (News)
https://www.swisstph.ch/en/news/news-detail/news/an-animated-cartoon-against-parasitic-worm-infections
strategy to reduce parasitic worm infections like soil-transmitted helminthiasis and schistosomiasis. However, if hygiene behaviour has not been changed, re-infections with these parasites can occur rapidly [...] 'Koko et les lunettes magiques' tells the story of a boy who discovers the many ways in which parasitic worms infect people's bodies and make them suffer from abdominal pain and diarrhoea. The animated [...] Côte d'Ivoire to raise their awareness and and make them minimise the...
Parasitic Worms in Siberia (News)
https://www.swisstph.ch/en/news/news-detail/news/parasitic-worms-in-siberia
clinical trial will test three different doses of Praziquantel, the standard treatment against parasitic worms, as well as one placebo group. In addition, pharmacokinetic parameters will be studied. First [...] institutions worldwide in discovering novel treatments and conducting clinical trials in the area of parasitic worms. Swiss TPH is also part of the Tomsk Opisthorchiasis Consortium (TOPIC), which brings together
Combination Therapy to Treat Parasitic Worm Infections (News)
https://www.swisstph.ch/en/news/20170829-combination-therapy-to-treat-parasitic-worm-infections
Parasitic worm infections are a major public health issue in low and middle-income countries. Soil-transmitted helminth (STH) infections affect 1.5 billion people globally. They are caused by different [...] different species of parasitic worms and transmitted by eggs present in human faeces, which contaminate the soil in areas where sanitation is poor. Two main drugs - albendazole and mebendazole – are used to treat [...] Jennifer Keiser, Swiss TPH. “We now have more options available to fight...
Toxic Sugar: Burnout for Parasites (News)
https://www.swisstph.ch/en/news/news-detail/news/toxic-sugar-burnout-for-parasites
ferment glucose, the parasite must first invest energy in the form of adenosine triphosphate (ATP). If ATP is consumed faster than it can be delivered this becomes fatal for the parasites. Such metabolism-induced [...] exploit glucose through other pathways. „The core problem of antimicrobial drug research is to kill parasites without harming our own cells,” says Pascal Mäser, Swiss TPH. “This new approach kills the Trypanosomes
Diagnosis of helminths depends on worm fecundity and the distribution of parasites within hosts (Publications)
Helminth transmission and morbidity are dependent on the number of mature parasites within a host; however, observing adult worms is impossible for many natural infections. An outstanding challenge is [...] fecundity (egg output per worm reduces due to crowding at high burdens) and the skewed distribution of parasites (majority of helminths aggregated in a small fraction of hosts). We address these questions for [...] al surveys (n = 641) where adult flukes were recovered. Using a mechanistic...
Special considerations for studies of extracellular vesicles from parasitic helminths: a community-led roadmap to increase rigour and reproducibility (Publications)
defining how extracellular vesicles (EVs) shape cross-species communication has grown rapidly. Parasitic helminths, worm species found in the phyla Nematoda and Platyhelminthes, are well-recognised ma
Malaria in Angola: recent progress, challenges and future opportunities using parasite demography studies (Publications)
Over the past two decades, a considerable expansion of malaria interventions has occurred at the national level in Angola, together with cross-border initiatives and regional efforts in southern Afric
