Clinical Trials Completed for a New Drug to Treat Parasitic Worm Infections in Infants (News)
https://www.swisstph.ch/en/news/clinicaltrialscompletedforanewdrug
unmet needs for preschool-aged children Schistosomiasis is one of the most damaging NTDs caused by parasitic worms. It affects the lives of around 240 million people. It is highly prevalent in sub-Saharan [...] groups and treated with a single dose of arpraziquantel. Stool and urine samples were analysed for parasite eggs. High efficacy was observed with cure rates close to or above 90%. Arpraziquantel treatment
Research & Development for Parasitic Worm Infections Lags Behind (News)
https://www.swisstph.ch/en/news/news-detail/news/research-development-for-parasitic-worm-infections-lags-behind
randomized trial with the drug moxidectin against Strongyloides stercoralis , a human pathogenic parasitic roundworm. We are in the Nam Bak district in the northern part of Laos. For the first time, we are [...] trials, it is simply wonderful to work hand-in-hand with our partners in the local communities where parasitic work infections are rife. Can you give me some examples of neglected tropical diseases (NTDs) and [...] and explain why we consider them to be “neglected”? Prominent examples of...
New Study Confirms Efficacy of Emodepside Against Parasitic Worm Infections (News)
https://www.swisstph.ch/en/news/news-detail/news/new-study-confirms-efficacy-of-emodepside-against-parasitic-worm-infections
Soil-transmitted helminth infections are caused by different species of parasitic worms, including whipworms, hookworms and roundworms. Worldwide, more than 1.5 billion people are infected with at least [...] anthelmintic candidate originally developed for veterinary use, has shown great potential in treating parasitic worm infections in humans. The results of a new Phase 2b trial, published today in The Lancet , [...] to become a critical treatment option, for individual cases or as part of...
Parasitic Worms and Liver Disease in Rural Laos (News)
https://www.swisstph.ch/en/news/parasitic-worms-and-liver-disease-in-rural-laos
People’s Democratic Republic (Lao PDR), infections with Opisthorchis viverrini liver fluke – a parasitic worm transmitted through consumption of raw fish – as well as type 2 diabetes are common, and severe [...] published yesterday in the peer-reviewed journal Annals of Medicine. Protective effect through parasitic worms? An unexpected result of the study was that the presence of O. viverrini infections was inversely [...] Helminths and Health group at Swiss TPH. “This might be explained by the...
A pyridyl-furan series developed from the Open Global Health Library block red blood cell invasion and protein trafficking in <em>Plasmodium... (Publications)
stage of the deadliest malarial parasite Plasmodium falciparum, from which eight inhibitors with low micromolar potency were found. Due to its combined potencies against parasite growth and inhibition of red [...] series lead compound (WEHI-518) was improved 250-fold to low nanomolar levels against parasite blood-stage growth. Parasites selected for resistance to a related compound, MMV396797, were also resistant to [...] PfPI4KIIIB blocks multiple stages of the parasite's life cycle and other...
Fake malaria and hidden parasites - the ambiguity of malaria (Publications)
Lay perspectives and health-seeking behaviour for malaria were investigated in an ethnographic study carried out in a village in south-eastern Tanzania. The inhabitants have easy access to hospital se
Prevalence and associated risk factors of intestinal parasitic infections among children in pastoralist and agro-pastoralist communities in the Adadle... (Publications)
BACKGROUND: Intestinal parasitic infections (IPIs) can cause illness, morbidity, and occasional mortality in children. Agro-pastoralist and pastoralist children in the Somali Regional State of Ethiopia [...] information, anthropometric measurements, and stool samples were obtained from included children. Parasites were identified microscopically using Kato-Katz and direct smear methods. Risk factors were assessed [...] PRINCIPAL FINDINGS: Overall prevalence of IPIs was 35%: 30.6% for single...
Parasitic, bacterial, viral, immune-mediated, metabolic and nutritional factors associated with nodding syndrome (Publications)
Nodding syndrome is a neglected, disabling and potentially fatal epileptic disorder of unknown aetiology affecting thousands of individuals mostly confined to Eastern sub-Saharan Africa. Previous stud
Sub-lethal exposure to chlorfenapyr reduces the probability of developing <em>Plasmodium falciparum</em> parasites in surviving Anopheles mosquitoes (Publications)
mosquitoes. As chlorfenapyr might also interfere with the metabolic mechanism of the Plasmodium parasite, we hypothesised that chlorfenapyr may provide additional transmission-reducing effects even if
