Strategies for Hookworm Eradication (SHE): Harnessing the parasite developmental keys for designing targeted clinical approaches (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/strategies-for-hookworm-eradication-she-harnessing-the-parasite-developmental-keys-for-designing-targeted-clinical-approaches
monotherapies to humans, there are grave concerns about the development of drug-resistance in human parasites. Thus, there is a pressing need for both the identification of new vaccine targets and the development [...] development of new anthelmintic drugs, particularly those that target novel molecular pathways in parasites. The overarching goal of this research proposal is to identify new intervention strategies against [...] ii) the identification of new vaccine targets that could be used to...
Multi-scale mathematical modelling of parasite, drug and vaccine interactions: optimising public health and disease elimination strategies (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/multi-scale-mathematical-modelling-of-parasite-drug-and-vaccine-interactions-optimising-public-health-and-disease-elimination-strategies
interventions is threatened by spreading resistance of mosquitos to insecticides and of malaria parasites to drugs. Succeeding toward elimination targets requires new tools, and we should prioritize tools [...] modelling can help understand malaria dynamics and interactions between malaria tools and the malaria parasite, human and mosquito hosts. Models can also help assess new tools such as vaccines beyond clinical
Understanding the human, parasite, vector and environmental interactions driving residual malaria transmission in Papua New Guinea (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/understanding-the-human-parasite-vector-and-environmental-interactions-driving-residual-malaria-transmission-in-papua-new-guinea
determinants of heterogeneity and residual malaria transmission in PNG and which human, vector and/or parasite behaviour/characteristics are the most important obstacles to elimination. This project aims to
The Parasite Reduction Ratio (PRR) assay version 2: standardized assessment of <em>Plasmodium falciparum </em>viability after antimalarial... (Publications)
fast rate of parasite killing or clearance. To determine these parameters, it is essential to discriminate viable from nonviable parasites, which is complicated by the fact that viable parasites can be me [...] reliably discriminate between viable and nonviable parasites. Conversely, the in vitro parasite reduction ratio (PRR) assay is able to measure viable parasites with high sensitivity. It provides valuable p [...] With artemisinin-resistant Plasmodium falciparum parasites emerging in...
One Health and citizen science approaches for contextualized community-led interventions tackling water-borne parasitic diseases in Chad (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/one-health-and-citizen-science-approaches-for-contextualized-community-led-interventions-tackling-water-borne-parasitic-diseases-in-chad
bringing the two concepts into action. The role of humans, animals and intermediate host snails in the parasites’ epidemiology will be investigated, as previous studies revealed high prevalence of schistosomiasis
Promising Drug Combination Treatment Against Parasitic Worm Infections (News)
https://www.swisstph.ch/en/news/promisingdrugcombinationtreatmentagainstparasiticworminfections
investigation. “There are several possible reasons for the low efficacy; one of them might be the parasite itself. It is conceivable that strains of T. trichiura vary in different geographical settings and
New Compounds Show Promise in Transforming Treatment of Parasitic Diseases (News)
https://www.swisstph.ch/en/news/news-detail/news/new-compounds-show-promise-in-transforming-treatment-of-parasitic-diseases
eliminate the parasites. “The compounds achieve this by targeting an enzyme called topoisomerase IIα, vital for DNA unwinding and replication,” explained Pascal Mäser, Head of the Parasite Chemotherapy [...] compounds called cyanotriazoles (CTs) that effectively inhibit the growth of trypanosomes, the parasites responsible for Chagas disease and African sleeping sickness. The results were published on 29 June [...] Novartis Global Health, and colleagues tested different substances against seven...
New Treatment for Human Parasitic Worm Infections Shows High Efficacy (News)
https://www.swisstph.ch/en/news/news-detail/news/new-treatment-for-human-parasitic-worm-infections-shows-high-efficacy
Soil-transmitted helminth infections are caused by different species of parasitic worms, including whipworms, hookworms and roundworms. Worldwide, more than 1.5 billion people are infected with at least
Public-private partnership launched to develop new drugs for parasitic worm infections (News)
https://www.swisstph.ch/en/news/news-detail/news/public-private-partnership-launched-to-develop-new-drugs-for-parasitic-worm-infections
pipeline, and put us on the path towards curative drugs that target one or more of these debilitating parasitic worm infections.” The HELP consortium will work on ‘nematode’ worms, which include both the filarial
Promising Treatment Alternative Against Parasitic Worm Infection (News)
https://www.swisstph.ch/en/news/news-detail/news/promising-treatment-alternative-against-parasitic-worm-infection
worldwide, with the highest infection rates in warm regions with poor sanitary infrastructure. The parasitic worm infections are often asymptomatic and predominantly affect the gastrointestinal tract, lungs [...] due to repeated mass drug administrations as part of control and elimination programmes for other parasitic worm infections such as onchocerciasis or lymphatic filariasis. Alternative treatment options are
