Response of Kampuchean strains of <em>Plasmodium falciparum</em> to antimalarials: in-vivo assessment of quinine and quinine plus tetracycline;... (Publications)
to quinine. The mean parasite density count on day 0 was 32,398 asexual parasites per microliter of blood. With a dosage of 1.5 g quinine base daily for 10 days the average parasite clearance time was 5 [...] 10 days, tetracycline 3 x 500 mg for 7 days. Parasite density counts on day 0 averaged 11,393 asexual parasites per microliter of blood. The average parasite clearance time was 5.9 days, and the average [...] test was evaluated at 7 and 10 days after the start of therapy. After 7 days only...
Spatial effects on the multiplicity of <em>Plasmodium falciparum</em> infections (Publications)
infected with multiple parasite clones. However, studies have shown also in areas with low overall parasite prevalence, infection with multiple parasite clones is a common occurrence. Mathematical models [...] intensity such as population parasite prevalence or multiplicity of infection (MOI). In traditionally highly malaria endemic regions where most of the population harbours malaria parasites, humans are often infected [...] present study an individual-based mathematical malaria transmission...
Three different <em>Plasmodium</em> species show similar patterns of clinical tolerance of malaria infection (Publications)
METHODS: Parasite densities measured in 24,386 presumptive malaria cases at two local health centres in the Wosera area of Papua New Guinea were compared with the distributions of parasite densities recorded [...] attributable disease and parasite density broadly follow similar age patterns. The logarithm of the incidence of acute illness is approximately proportion to the logarithm of the parasite density for all three [...] BACKGROUND: In areas where malaria endemicity is high, many people...
Three different <em>Plasmodium</em> species show similar patterns of clinical tolerance of malaria infection (Publications)
METHODS: Parasite densities measured in 24,386 presumptive malaria cases at two local health centres in the Wosera area of Papua New Guinea were compared with the distributions of parasite densities recorded [...] attributable disease and parasite density broadly follow similar age patterns. The logarithm of the incidence of acute illness is approximately proportion to the logarithm of the parasite density for all three [...] BACKGROUND: In areas where malaria endemicity is high, many people...
Spatial effects on the multiplicity of <em>Plasmodium falciparum</em> infections (Publications)
infected with multiple parasite clones. However, studies have shown also in areas with low overall parasite prevalence, infection with multiple parasite clones is a common occurrence. Mathematical models [...] intensity such as population parasite prevalence or multiplicity of infection (MOI). In traditionally highly malaria endemic regions where most of the population harbours malaria parasites, humans are often infected [...] present study an individual-based mathematical malaria transmission...
Probing <em>Plasmodium falciparum</em> sexual commitment at the single-cell level (Publications)
l diversity in parasite populations containing complex mixtures of different life-cycle stages and developmental programs, with important implications for our understanding of parasite biology and the [...] Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure. Here we apply single cell transcriptomics to unravel [...] unravel the program inducing sexual differentiation in Plasmodium falciparum. Para...
Probing <em>Plasmodium falciparum</em> sexual commitment at the single-cell level (Publications)
l diversity in parasite populations containing complex mixtures of different life-cycle stages and developmental programs, with important implications for our understanding of parasite biology and the [...] Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure. Here we apply single cell transcriptomics to unravel [...] unravel the program inducing sexual differentiation in Plasmodium falciparum. Para...
Basic Malaria Research (Page)
https://www.swisstph.ch/en/topics/malaria/basic-malaria-research
biology of malaria blood stage parasites. These parasite forms are responsible for all malaria-related morbidity and mortality as well as for the transmission of parasites between humans via the mosquito [...] allowing the parasite’s survival in its host cell. We use state-of-the-art molecular-genetic and cell-biological methods and produce a substantial number of transgenic parasites. In these parasites we study [...] conversion, which facilitate chronic blood infection and parasite...
<em>Plasmodium falciparum</em> erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma (Publications)
falciparum, the malarial parasite. PfEMP-1, present on the surface of infected host erythrocytes, mediates erythrocyte binding to vascular endothelium, enabling the parasite to avoid splenic clearance [...] PfEMP-1 by comparing host cell responses to erythrocytes infected with either wild-type parasites or transgenic parasites lacking PfEMP-1. We showed that PfEMP-1 suppresses the production of the cytokine i [...] alphabeta-T cells. These data demonstrate a parasite strategy for downregulating...
<em>Plasmodium falciparum</em> erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma (Publications)
falciparum, the malarial parasite. PfEMP-1, present on the surface of infected host erythrocytes, mediates erythrocyte binding to vascular endothelium, enabling the parasite to avoid splenic clearance [...] PfEMP-1 by comparing host cell responses to erythrocytes infected with either wild-type parasites or transgenic parasites lacking PfEMP-1. We showed that PfEMP-1 suppresses the production of the cytokine i [...] alphabeta-T cells. These data demonstrate a parasite strategy for downregulating...
