Malaria Host Interactions (Page)
https://www.swisstph.ch/en/about/mpi/malaria-host-interactions
studying the molecular interface between malaria parasites and their human host. Recent findings revealed the existence of intimate links between parasite metabolism, gene regulation and the host environment [...] Plasmodium falciparum During their life cycle, malaria parasites enter different milieus in both the vertebrate host and the mosquito vector. Parasites have to adapt to these changing conditions and it is [...] environment. This also holds true for the intra-erythrocytic stages of the ...
Contraintes parasitaires des cultures maraîchères en Côte d'Ivoire (Publications)
bemisia tabaci. The main parasitic problems on cabbage are the insects Plutella zylostella and Helulla undalis and the bacterial rotting due to Erwinia carotovora. The mani parasitic problems on melon are [...] This study based on the identification of the parasitic problems of four vegetable crops in three agro-ecological areas of Côte d'Ivoire, allowed us to indentity the main insects and diseases of cabbage [...] and tomato in the north, middle and south areas. Tomato crop was observes to...
Contraintes parasitaires des cultures maraîchères en Côte d'Ivoire (Publications)
bemisia tabaci. The main parasitic problems on cabbage are the insects Plutella zylostella and Helulla undalis and the bacterial rotting due to Erwinia carotovora. The mani parasitic problems on melon are [...] This study based on the identification of the parasitic problems of four vegetable crops in three agro-ecological areas of Côte d'Ivoire, allowed us to indentity the main insects and diseases of cabbage [...] and tomato in the north, middle and south areas. Tomato crop was observes to...
The PHIST protein GEXP02 targets the host cytoskeleton during sexual development of <em>Plasmodium falciparum</em> (Publications)
A hallmark of the biology of Plasmodium falciparum blood stage parasites is their extensive host cell remodeling, facilitated by parasite proteins that are exported into the erythrocyte. Although this [...] as well as other exported parasite proteins. This indicates that GEXP02 targets the erythrocyte cytoskeleton and is likely involved in its remodeling. GEXP02 knock-out parasites show no obvious phenotype [...] this area has received extensive attention, only a few exported parasite proteins...
The PHIST protein GEXP02 targets the host cytoskeleton during sexual development of <em>Plasmodium falciparum</em> (Publications)
A hallmark of the biology of Plasmodium falciparum blood stage parasites is their extensive host cell remodeling, facilitated by parasite proteins that are exported into the erythrocyte. Although this [...] as well as other exported parasite proteins. This indicates that GEXP02 targets the erythrocyte cytoskeleton and is likely involved in its remodeling. GEXP02 knock-out parasites show no obvious phenotype [...] this area has received extensive attention, only a few exported parasite proteins...
An atypical mitochondrial carrier that mediates drug action in <em>Trypanosoma brucei</em> (Publications)
the action of a group of anti-parasitic choline analogs. Depletion of TbMCP14 by inducible RNAi in both bloodstream and procyclic forms increased resistance of parasites towards the compounds by 7-fold [...] , over-expression of the carrier in procyclic forms increased parasite susceptibility more than 13-fold. Metabolomic analyses of parasites over-expressing TbMCP14 showed increased levels of the proline [...] production. The generation of TbMCP14 knock-out parasites showed that the carrier is...
An atypical mitochondrial carrier that mediates drug action in <em>Trypanosoma brucei</em> (Publications)
the action of a group of anti-parasitic choline analogs. Depletion of TbMCP14 by inducible RNAi in both bloodstream and procyclic forms increased resistance of parasites towards the compounds by 7-fold [...] , over-expression of the carrier in procyclic forms increased parasite susceptibility more than 13-fold. Metabolomic analyses of parasites over-expressing TbMCP14 showed increased levels of the proline [...] production. The generation of TbMCP14 knock-out parasites showed that the carrier is...
Additional blood meals increase sporozoite infection in <em>Anopheles</em> mosquitoes but not <em>Plasmodium falciparum</em> genetic diversity (Publications)
impact of an additional non-infectious blood meal on parasite development. We also assess parasite genetic diversity at the blood stage level of the parasite in the human host and of the sporozoites in the [...] not substantially affect the genetic diversity of sporozoites in the mosquito. The most abundant parasite genotypes in the human blood were transmitted to mosquitoes, suggesting that there was no preferential [...] This study underlines the importance of additional mosquito blood meals...
Differential infectivity of Plasmodium for mosquitoes (Publications)
parallel processes in three sets of mosquito-parasite models, suggesting that parasite-vector specificity may depend on a balance between speed of parasite development versus speed of formation of the [...] Moreover, there are many other plasmodial parasites of other mammals and birds, that can infect other genera of mosquito. What determines this level of vector-parasite specificity? Malarial gametocytes, ingested
New fluorescence markers to distinguish co-infecting <em>Trypanosoma brucei</em> strains in experimental multiple infections (Publications)
important factors in disease evolution, parasite transmission dynamics, and the evolution of drug resistance. However, the distinction of co-infecting parasite genotypes and the tracking of their dynamics [...] inserted into the genome of Trypanosoma brucei to phenotypically label live parasites of all life cycle stages. If different parasite strains are labelled with different colours they can be easily distinguished [...] The use of fluorescence activated cell sorting (FACS) allowed rapid and...
