Exploring seasonal malaria transmission dynamics and patterns of drug resistance: a molecular epidemiology study in two border areas of Côte d'Ivoire... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/exploring-seasonal-malaria-transmission-dynamics-and-patterns-of-drug-resistance-a-molecular-epidemiology-study-in-two-border-areas-of-cote-divoire-and-burkina-faso
ant parasites to transmission, and by characterizing parasite genetic diversity, population structure, and genetic relatedness. In addition, the impact of interventions such as SMC on the parasite populations [...] intense. In general, malaria infections peak during the wet season and decrease in the dry season. The parasite reservoir that persists until the end of the dry season, as well as importation from other areas [...] disease burden in the areas for decades. However, researchers have yet...
The catalytic subunit of <em>Plasmodium falciparum</em> casein kinase 2 is essential for gametocytogenesis (Publications)
cellular compartments in eukaryotes. In the malaria parasite Plasmodium falciparum, PfCK2 is vital for asexual proliferation of blood-stage parasites. Here, we applied CRISPR/Cas9-based gene editing to [...] , the sexual forms of the parasite that are essential for malaria transmission. We show that PfCK2alpha localizes to the nucleus and cytoplasm in asexual and sexual parasites alike. Conditional knockdown [...] PfCK2alpha is not only essential for asexual but also sexual development of P....
Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on... (Publications)
unique to trypanosomatid parasites and a target for lead discovery programs. Various inhibitor scaffolds have emerged in the past, exhibiting moderate affinity for the parasite enzyme. Herein we show that [...] conjugates is enhanced over that of the respective parent inhibitors. They show K(ic) values for the parasite enzyme down to 0.9+/-0.1 microm and exhibit high selectivity for TR over human glutathione reductase [...] olar range against Trypanosoma brucei rhodesiense and Trypanosoma cruzi,...
The catalytic subunit of <em>Plasmodium falciparum</em> casein kinase 2 is essential for gametocytogenesis (Publications)
cellular compartments in eukaryotes. In the malaria parasite Plasmodium falciparum, PfCK2 is vital for asexual proliferation of blood-stage parasites. Here, we applied CRISPR/Cas9-based gene editing to [...] , the sexual forms of the parasite that are essential for malaria transmission. We show that PfCK2alpha localizes to the nucleus and cytoplasm in asexual and sexual parasites alike. Conditional knockdown [...] PfCK2alpha is not only essential for asexual but also sexual development of P....
Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on... (Publications)
unique to trypanosomatid parasites and a target for lead discovery programs. Various inhibitor scaffolds have emerged in the past, exhibiting moderate affinity for the parasite enzyme. Herein we show that [...] conjugates is enhanced over that of the respective parent inhibitors. They show K(ic) values for the parasite enzyme down to 0.9+/-0.1 microm and exhibit high selectivity for TR over human glutathione reductase [...] olar range against Trypanosoma brucei rhodesiense and Trypanosoma cruzi,...
Antiprotozoal and antihelminthic properties of plants ingested by wild Japanese macaques (<em>Macaca fuscata yakui</em>) in Yakushima Island (Publications)
methanolic extracts of 45 plant parts were tested in vitro against important parasites of humans, including four protozoan parasites Plasmodium falciparum, Trypanosoma brucei rhodesiense, T. cruzi and Leishmania [...] consume plants for medicinal purposes (self-medication) as well, particularly when infected with parasites and pathogens (bacteria, viruses, microbes). Interestingly, some of the plants they consume are [...] or may have potential uses for humans. MATERIALS AND METHODS: As part of...
A 39-amino-acid C-terminal truncation of GDV1 disrupts sexual commitment in<em> Plasmodium falciparum</em> (Publications)
requires the parasite to change from a continuously growing asexual parasite form growing in the blood to a sexually differentiated form, the gametocyte. Only a small subset of asexual parasites differentiates [...] Malaria is a mosquito-borne disease caused by apicomplexan parasites of the genus Plasmodium. Completion of the parasite's life cycle depends on the transmission of sexual stages, the gametocytes, from [...] to the mosquito vector. Sexual commitment occurs in only a small fraction of...
A 39-amino-acid C-terminal truncation of GDV1 disrupts sexual commitment in<em> Plasmodium falciparum</em> (Publications)
requires the parasite to change from a continuously growing asexual parasite form growing in the blood to a sexually differentiated form, the gametocyte. Only a small subset of asexual parasites differentiates [...] Malaria is a mosquito-borne disease caused by apicomplexan parasites of the genus Plasmodium. Completion of the parasite's life cycle depends on the transmission of sexual stages, the gametocytes, from [...] to the mosquito vector. Sexual commitment occurs in only a small fraction of...
Antiprotozoal and antihelminthic properties of plants ingested by wild Japanese macaques (<em>Macaca fuscata yakui</em>) in Yakushima Island (Publications)
methanolic extracts of 45 plant parts were tested in vitro against important parasites of humans, including four protozoan parasites Plasmodium falciparum, Trypanosoma brucei rhodesiense, T. cruzi and Leishmania [...] consume plants for medicinal purposes (self-medication) as well, particularly when infected with parasites and pathogens (bacteria, viruses, microbes). Interestingly, some of the plants they consume are [...] or may have potential uses for humans. MATERIALS AND METHODS: As part of...
Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in<em> Plasmodium falciparum</em> protein export (Publications)
stage parasites export a large number of proteins into their host erythrocyte to change it from a container of predominantly hemoglobin optimized for the transport of oxygen into a niche for parasite propagation [...] the PV membrane (PVM), highlighting protein translocation in the parasite periphery as a general means in protein export of malaria parasites [...] propagation. To understand this process, it is crucial to know which parasite proteins are exported into the host cell. This has been...
