Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in<em> Plasmodium falciparum</em> protein export (Publications)
stage parasites export a large number of proteins into their host erythrocyte to change it from a container of predominantly hemoglobin optimized for the transport of oxygen into a niche for parasite propagation [...] the PV membrane (PVM), highlighting protein translocation in the parasite periphery as a general means in protein export of malaria parasites [...] propagation. To understand this process, it is crucial to know which parasite proteins are exported into the host cell. This has been...
Excretory/secretory products from the gastrointestinal nematode <em>Trichuris muris</em> (Publications)
strategies used by these parasites to modulate the host immune system. In this regard, molecules released by parasites have been attributed crucially important roles in host-parasite negotiations. We characterized [...] excretory/secretory (E/S) microRNA (miRNA) and protein profiles from the mouse gastrointestinal nematode parasite Trichuris muris. Released miRNAs were subjected to miRNA sequencing and E/S proteins were analysed
Excretory/secretory products from the gastrointestinal nematode <em>Trichuris muris</em> (Publications)
strategies used by these parasites to modulate the host immune system. In this regard, molecules released by parasites have been attributed crucially important roles in host-parasite negotiations. We characterized [...] excretory/secretory (E/S) microRNA (miRNA) and protein profiles from the mouse gastrointestinal nematode parasite Trichuris muris. Released miRNAs were subjected to miRNA sequencing and E/S proteins were analysed
Heterogeneous distribution of <em>Plasmodium falciparum</em> drug resistance haplotypes in subsets of the host population (Publications)
children and new infections, whereas parasites harbouring fewer mutations were more frequent in adults. CONCLUSION: The reduced frequency of highly mutated parasites in chronic infections in adults is likely [...] underlying hypothesis is that mutations associated with drug resistance incur fitness costs to the parasite in absence of drug pressure. The distribution of drug resistance haplotypes in different subsets [...] persistent infections. METHODS: Mutations associated with antimalarial drug...
Heterogeneous distribution of <em>Plasmodium falciparum</em> drug resistance haplotypes in subsets of the host population (Publications)
children and new infections, whereas parasites harbouring fewer mutations were more frequent in adults. CONCLUSION: The reduced frequency of highly mutated parasites in chronic infections in adults is likely [...] underlying hypothesis is that mutations associated with drug resistance incur fitness costs to the parasite in absence of drug pressure. The distribution of drug resistance haplotypes in different subsets [...] persistent infections. METHODS: Mutations associated with antimalarial drug...
Anti-trypanosomatid and antiplasmodial activities of alkaloids from <em>Hippeastrum</em> species (Publications)
activity against all the evaluated parasites, especially T. b. rhodesiense. Candimine merits deeper research regarding its effect against trypanosomatid parasites as a lead compound for the development [...] Diseases caused by trypanosomatid parasites like human African trypanosomiasis (HAT), Chagas disease (CD), leishmaniasis, and malaria are persistent health problems in developing countries that still demand [...] Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and...
New Discovery Unravels Malaria Invasion Mechanism (News)
https://www.swisstph.ch/en/news/news-detail/news/new-discovery-unravels-malaria-invasion-mechanism
malaria parasites in the red blood cells. Key component found for malaria invasion P. falciparum is known to invade human red blood cells, but the precise details of the targets that the parasite binds to [...] the parasite inhibitory activity of CyRPA-specific antibodies” said Gerd Pluschke, Group Leader of Molecular Immunology at Swiss TPH, and co-corresponding author of the publication. Malaria parasite adapted [...] species-specific targeting of malaria parasites. In this study, we show that...
Measures of clinical malaria in field trials of interventions against <em>Plasmodium falciparum</em> (Publications)
the intervention has its effect by modifying the force of infection, the parasite density, or the risk of pathology at given parasite density. METHODS: Three different sets, each of 500 Phase IIb or III malaria [...] effects of vaccination in a homogeneous trial population. The relationships between morbidity and parasite density and the performance of different case definitions for clinical malaria were analysed using [...] using conventional likelihood ratio tests to compare incidence of...
Measures of clinical malaria in field trials of interventions against <em>Plasmodium falciparum</em> (Publications)
the intervention has its effect by modifying the force of infection, the parasite density, or the risk of pathology at given parasite density. METHODS: Three different sets, each of 500 Phase IIb or III malaria [...] effects of vaccination in a homogeneous trial population. The relationships between morbidity and parasite density and the performance of different case definitions for clinical malaria were analysed using [...] using conventional likelihood ratio tests to compare incidence of...
Ensuring transmission through dynamic host environments: host-pathogen interactions in <em>Plasmodium </em>sexual development (Publications)
vaccines. The identification of parasite factors that alter sexual differentiation, including extracellular vesicles and a master transcriptional regulator, suggest that parasites make epigenetically controlled [...] especially host cell remodeling and sequestration in the bone marrow, highlight open questions regarding parasite homing to the tissue, transmigration across the vascular endothelium, and maturation in the parenchyma [...] parenchyma. Novel molecular and translational tools will...
